Reactome: A Curated Pathway Database
All 6 results
Pathways (3) Reactions (2) Proteins (1) Others (0)
Protein: UniProt:Q99758 ABCA3 (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: ABC-family proteins mediated transport (Homo sapiens)
The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and p
Last changed: 2014-11-21 19:49:01

Reaction: ABCAs mediate lipid influx (Homo sapiens)
ABCA3 plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol (Klugbauer and Hofmann 1996, Yamano et al. 2001). Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921] (Shulenin et al. 2004). The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et
Last changed: 2014-11-25 21:08:03

Reaction: ABCAs mediate lipid efflux (Homo sapiens)
ABCA3 plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol (Klugbauer and Hofmann 1996, Yamano et al. 2001). Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921] (Shulenin et al. 2004). The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et
Last changed: 2014-11-21 14:40:22

Pathway: ABCA transporters in lipid homeostasis (Homo sapiens)
A defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in chronic inflammatory diseases (Schmitz and Kaminski 2001, Schmitz et al. 2000)
Last changed: 2014-11-21 19:49:01