Reactome: A Curated Pathway Database
All 10 results
Pathways (6) Reactions (2) Proteins (1) Others (1)
Protein: UniProt:O60706 ABCC9 (Homo sapiens)
Last changed: 2014-11-25 21:16:27

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: Neuronal System (Homo sapiens)
The human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication among this astronomical number of elements. This communication occurs across synapses, the functional connection between neurons. Synapses can be divided into two general classes: electrical synapses and che
Last changed: 2014-11-21 19:49:01

Pathway: Potassium Channels (Homo sapiens)
Potassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation of action potentials in cardiac muscle and help release of insulin form pancreatic beta cells. Broadly K+ channels are classified into voltage gated K+ channels, Hyperpolarization activated cyclic nucleo
Last changed: 2014-11-21 19:49:01

Pathway: ABC-family proteins mediated transport (Homo sapiens)
The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and p
Last changed: 2014-11-21 19:49:01

Pathway: Inwardly rectifying K+ channels (Homo sapiens)
Inwardly rectifying K+ channels (Kir channels) show an inward rather than outward (like the voltage gated K+ channels) flow of K+ thereby contributing to maintenance of resting membrane potential and regulation of action potential in excitable tissue. Kir channels are found in a variety of cell types such as cardiac myocytes, neurons, blood cells, osteoblasts, glial cells, epithelial cells, and oocyte
Last changed: 2014-11-21 14:40:22

Pathway: ATP sensitive Potassium channels (Homo sapiens)
ATP sensitive K+ channels couple intracellular metabolism with membrane excitability. These channels are inhibited by ATP so are open in low metabolic states and close in high metabolic states, resulting in membrane depolarization triggering responses such as insulin secretion, modulation of vascular smooth muscle and cardioprotection. The channel comprises four Kir6.x subunits and four regulatory sulp
Last changed: 2014-11-21 14:40:22

Reaction: The ABCC family mediates organic anion transport (Homo sapiens)
The multidrug resistance associated protein (MRPs) subfamily of the ABC transporter family can transport a wide and diverse range of organic anions that can be endogenous compounds and xenobiotics and their metabolites. All human MRPs (except MRP9) can mediate these transport reactions (Deeley et al. 2006). Separately, specific reactions have also been annotated to describe the roles of ABCC4 in plat
Last changed: 2014-11-21 19:49:01

Reaction: Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)
In muscle cells such as cardiac, skeletal, vascular and nonvascular smooth muscle, ATP sensitive K+ channels assemble as octamers of four Kir 6.x subunits and four low-affinity sulfonyl urea receptor 2 subunits (SUR2). The human gene encoding SUR2 gives rise to two splice variants, SUR2A and SUR2B. These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates a
Last changed: 2014-11-25 21:08:03

Complex: ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane] (Homo sapiens)
ATP sensitive K+ channels-inwardly rectifying (SUR2)
Last changed: 2011-07-04 10:08:09