Reactome: A Curated Pathway Database
Results 1 to 10 of 27
Pathways (17) Reactions (9) Proteins (1) Others (0)
Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Pathway: Signalling by NGF (Homo sapiens)
Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR,
Last changed: 2014-11-21 19:49:01

Pathway: NGF signalling via TRKA from the plasma membrane (Homo sapiens)
Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the like
Last changed: 2014-11-21 19:49:01

Pathway: p75 NTR receptor-mediated signalling (Homo sapiens)
Besides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a number of downstream signalling events controlling survival, death, proliferation, and axonogenesis, according to the cellular context. p75NTR is devoid of enzymatic activity, and signals by recruiting othe
Last changed: 2014-11-21 14:40:22

Pathway: TRKA activation by NGF (Homo sapiens)
Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible
Last changed: 2014-11-21 06:36:34

Pathway: NADE modulates death signalling (Homo sapiens)
NADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-epsilon protein (Kimura MT et al, 2001)
Last changed: 2014-11-20 19:55:10

Pathway: Retrograde neurotrophin signalling (Homo sapiens)
Neurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrograd ... is a specialized vesicle containing ligand (NGF, BDNF) bound to its activated TRK receptor, together with activated downstream signalling proteins, transported by motor proteins (dyneins) from nerve terminals to remote cell bodies, where the receptors trigger signalling cascades ...
Last changed: 2014-11-21 14:40:22

Pathway: Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis ... ature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. TRKA signalling protects neurons from apoptosis. The molecular mechanisms involved in p75NTR-apoptosis are not well understood. The death signalling requires activa ...
Last changed: 2014-11-21 14:40:22

Pathway: Regulated proteolysis of p75NTR (Homo sapiens)
p75NTR undergoes a process of regulated intramembrane proteolysis (RIP) similar to other transmembra ... p75 appears to be regulated by neurotrophin (NGF, BDNF) binding to TRKA or TRKB. p75NTR processing also occurs in response to MAG in cerebellar granule neurons ...
Last changed: 2014-11-21 06:36:34

Pathway: p75NTR signals via NF-kB (Homo sapiens)
The NF-kB pathway is an important pro-survival signalling pathway activated by mature NGF, but not BDNF or NT-3, through p75NTR. It is unclear whether TRKA activity also affects NF-kB activation
Last changed: 2014-11-21 14:40:22

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