Reactome: A Curated Pathway Database
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Pathways (2) Reactions (5) Proteins (1) Others (13)
Protein: UniProt:P49715 CEBPA (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2014-11-21 19:49:01

Pathway: Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During ... lets. However, it is the subsequent inductions of CEBPA and PPARG that are critical for morphological, biochemical and functional adipocytes. Ectopic expression of CEBPB alone is capable of inducing substantial adipocyte differentiation in fibroblasts while CEBPD has a minimal effect. CEBPB is up ...
Last changed: 2014-11-21 06:36:34

Gene: ENSEMBL:ENSG00000245848 CEBPA (Homo sapiens)
Last changed: 2014-11-16 08:18:29

Reaction: Expression of CEBPA (Homo sapiens)
The CEBPA gene is transcribed to yield mRNA and the mRNA is translated to yield protein
Last changed: 2014-11-20 16:55:13

Reaction: Expression of Adiponectin (Homo sapiens)
The Adiponectin gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of Adiponectin is upregulated during adipogenesis by C/EBPalpha (CEBPA), PPARG, and CEBPB (Segawa et al. 2009, Qiao et al. 2005, Iwaki et al. 2003, Kita et al. 2005)
Last changed: 2014-11-16 08:21:03

Reaction: Expression of PPARG (Homo sapiens)
The transcription factors CEBPB, CEBPD, and KLF5 simultaneously bind the PPARG promoter and synergis ... dipocyte differentiation but then are replaced by CEBPA within 10 days. CEBPA and other factors may be responsible for long term maintenance of PPARG expression and the differentiated state. Pre-adipose tissue contains both the widely expressed PPARG isoform 1 mRNA and the more tissue-specific P ...
Last changed: 2014-11-20 16:55:13

Reaction: Expression of Leptin (Homo sapiens)
The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996)
Last changed: 2014-11-16 08:21:03

Reaction: Maintenance of PPARG expression in differentiated adipocytes (Homo sapiens)
In mouse, by 10 days after induction of adipocyte differentiation Cebpa, but neither Cebpb nor Cebpd, is detectable at the Pparg promoter. While adipocyte differentiation can proceed without Cebpa, adipocytes differentiated from Cebpa-knockout cells are insulin insensitive due to a defect in Glut4 (Slc2a4) vesicle trafficking
Last changed: 2014-11-20 16:55:13

Activation: 'CEBPA [nucleoplasm]' positively regulates 'Expression of Adiponectin'
C/EBPalpha (CEBPA) binds the promoter of the Adiponectin gene and activates transcription
Last changed: 2011-12-22 17:06:51

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