Reactome: A Curated Pathway Database
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Pathways (8) Reactions (2) Proteins (1) Others (2)
Protein: UniProt:P07510 CHRNG (Homo sapiens)
Last changed: 2014-11-25 21:16:27

Pathway: Neuronal System (Homo sapiens)
The human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication among this astronomical number of elements. This communication occurs across synapses, the functional connection between neurons. Synapses can be divided into two general classes: electrical synapses and che
Last changed: 2014-11-21 19:49:01

Pathway: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (Homo sapiens)
The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body
Last changed: 2014-11-21 19:49:01

Pathway: Transmission across Chemical Synapses (Homo sapiens)
Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synapti
Last changed: 2014-11-21 19:49:01

Pathway: Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
Presynaptic terminal acetylcholine receptors are located at or near nerve terminal and modulate the release of neurotransmitter such as glutamate, noradrenaline and dopamine. Activation of presynaptic acetylcholine receptors leads to influx of Ca2+ and sufficient increase in local Ca2+ concentrations which could be due to either direct or indirect Ca2+ entry. Direct Ca2+ entry through acetylcholine rec
Last changed: 2014-11-21 14:40:22

Pathway: Activation of Nicotinic Acetylcholine Receptors (Homo sapiens)
Nicotinic acetylcholine receptors (nAchR) are a subtype of acetylcholine receptors that are activated by nicotine and allow the influx of monovalent (sodium) and divalent cations(calcium), however, the permeability of sodium and/or calcium maybe high or low depending on the subunit composition of the receptor. Nicotinic acetylcholine receptors are expressed widely in the central and peripheral nervous
Last changed: 2014-11-21 14:40:22

Pathway: Highly sodium permeable acetylcholine nicotinic receptors (Homo sapiens)
Nicotinic acetylcholne receptors that have low Ca2+ permeability allow the influx of Na+ which causes depolarization of the membrane initiating voltage dependent responses such as activation of voltage dependent opening of Ca2+ channels and thus eliciting an increase in Ca2+ and downstream signaling. These receptors could be found in both presynaptic and postsynaptic terminals
Last changed: 2014-11-21 14:40:22

Pathway: Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Nicotinic acetylcholine receptors are found in the postsynaptic terminals and these receptors are responsible in mediating postsynaptic currents. Most common types of postsynaptic nicotinic acetylcholine receptors are homomeric alpha 7 containing acetylcholine receptors. The densities of acetylcholine receptors are found to be similar to NMDA and AMPA receptors at these sites. Nicotinic acetylcholine r
Last changed: 2014-11-21 14:40:22

Pathway: Acetylcholine Binding And Downstream Events (Homo sapiens)
Last changed: 2014-11-21 14:40:22

Reaction: Activation of highly sodium permeable nicotinic acetylcholine receptors (Homo sapiens)
Nicotinic acetylcholine receptors containing aplha4(2) beta2 (3) and alpha3(2) beta4(3) are selectively highly Na+ permeable upon activation of these receptors by acetylcholine
Last changed: 2014-11-21 14:40:22

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