Reactome: A Curated Pathway Database
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Pathways (9) Reactions (8) Proteins (3) Others (9)
Protein: UniProt:P26358 DNMT1 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Gene Expression (Homo sapiens)
Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are
Last changed: 2014-11-21 19:49:01

Pathway: Chromatin organization (Homo sapiens)
Chromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. These processes include histone modification, DNA modification, and transcription. The modifications are bound by specific proteins that alter the conformat
Last changed: 2014-11-21 19:49:01

Pathway: DNA methylation (Homo sapiens)
Methylation of cytosine is catalyzed by a family of DNA methyltransferases (DNMTs): DNMT1, DNMT3A, and DNMT3B transfer methyl groups from S-adenosylmethionine to cytosine, producing 5-methylcytosine and homocysteine (reviewed in Klose and Bird 2006, Ooi et al. 2009, Jurkowska et al. 2011, Moore et al. 2013). (DNMT2 appears to methylate RNA rather than DNA.) DNMT1, the first enzyme discovered, preferent
Last changed: 2014-11-21 06:36:34

Pathway: NoRC negatively regulates rRNA expression (Homo sapiens)
Only about half of the rRNA gene copies in a cell are expressed. The remaining copies are silenced b ... HDAC1, HDAC2) and DNA Methyltransferase 1 and 3b (DNMT1, DNMT3b). Interaction with a Histone Methyltransferase is also assumed. Deacetylation of histones is required for DNA methylation but not for methylation of histone H3. Methylcytosine at the rRNA promoter binds Methyl Domain Binding protein 2 ( ...
Last changed: 2014-11-21 06:36:34

Reaction: DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)
DNMT1 transfers a methyl group from S-adenosylmethionine to the 5-position of the cytosine ring of cytosine residues in DNA. Purified human DNMT1 shows a 7 to 21-fold preference for hemimethylated CG motifs in DNA compared to unmethylated CG motifs (Pradhan et al. 1999) thus DNMT1 tends to maintain existing methylation through DNA replication. The binding of the CXXC motif of DNMT1 to cytosine in symme
Last changed: 2014-11-21 06:36:34

Reaction: UHRF1:Chromatin binds DNMT1 (Homo sapiens)
As inferred from the mouse homolog, UHRF1 associates with hemimethylated DNA and histone H3 tails methylated at lysine-9. UHRF1 recruits and tethers DNMT1 (Bostick et al. 2007). The association of UHRF1 with DNMT1 occurs preferentially during S-phase when DNA is hemimethylated as the newly replicated strand remains transiently unmethylated (Zhang et al. 2011, Hervouet et al. 2012). DNMT1 also forms com
Last changed: 2014-11-21 06:36:34

Reaction: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)
DNA methyltransferases (DNMTs) associate with EZH2 of the Polycomb Repressive Complex 2 (PRC2) and methylate the 5 position of the cytosine ring in DNA (Vire et al. 2006). The histone methyltransferase activity of EZH2 also trimethylates lysine-27 of histone H3 (H3K27me3). The promoters of the MYT, WNT1, KCNA1, and CNR1 genes are methylated on cytosine by the DNMT:PRC2 complex however not all loci tha
Last changed: 2014-11-21 06:36:34

Pathway: Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA sequence. Originally the definition applied only to heritability across generations but later also encompassed the heritable changes that occur during cellular differentiation within one organism. Molecul
Last changed: 2014-11-21 14:40:22

Pathway: Chromatin modifying enzymes (Homo sapiens)
Eukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect it from damage. Access to DNA is achieved by highly regulated local chromatin decondensation. The 'building block' of chromatin is the nucleosome. This contains ~150 bp of DNA wrapped around a histon
Last changed: 2014-11-21 19:49:01

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