Reactome: A Curated Pathway Database
All 5 results
Pathways (2) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q8NF50 DOCK8 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2015-03-06 23:15:47

Pathway: Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MK's mature, the polyploid nucleus becomes horseshoe-shap
Last changed: 2015-03-06 23:15:47

Reaction: DOCKs bind to RhoGEFs (Homo sapiens)
Members of the Dedicator of cytokinesis (DOCK) family, also known as the Dock180 superfamily, are Rho GTPase guanine nucleotide exchange factors (GEFs), modulating Rho GTPase activity (Cote & Vuori 2002). All eleven human members share the presence of two evolutionarily conserved protein domains, termed DHR-1 and DHR-2 (Cote & Vuori 2007). The DHR-2 domains of several DOCKs interact with the nucleotide
Last changed: 2015-03-06 18:40:03

Complex: DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
Last changed: 2010-11-11 16:37:46