Reactome: A Curated Pathway Database
Results 1 to 10 of 42
Pathways (8) Reactions (16) Proteins (2) Others (16)
Protein: UniProt:Q99814 EPAS1 (Homo sapiens)
Last changed: 2014-11-25 21:16:27

Pathway: Cellular responses to stress (Homo sapiens)
Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential to the maintenance of tissue homeostasis (Kultz 2005)
Last changed: 2014-11-21 19:49:01

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2014-11-21 19:49:01

Pathway: Regulation of Hypoxia-inducible Factor (HIF) by oxygen (Homo sapiens)
In the presence of oxygen members of the transcription factor family HIF-alpha, comprising HIF1A, HIF2A (EPAS1), and HIF3A, are hydroxylated on proline residues by PHD1 (EGLN2), PHD2 (EGLN1), and PHD3 (EGLN3) and on asparagine residues by HIF1AN (FIH) (reviewed in Pouyssegur et al. 2006, Semenza 2007, Kaelin and Ratcliffe 2008, Nizet and Johnson 2009, Brahimi-Horn and Pouyssegur 2009, Majmundar et al.
Last changed: 2014-11-21 14:40:22

Reaction: Expression of EPAS1 (HIF2A) (Homo sapiens)
The EPAS1 (HIF2A) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EPAS1 is expressed in most adult tissues, but not in peripheral blood leukocytes (Tian et al. 1997). Normoxia causes constitutive oxygen-dependient hydroxylation of EPAS1 on asparagine and proline residues, resulting in degradation of EPAS1 via ubiquitinylation. Hypoxia therefore inhibits degradation of EPA
Last changed: 2014-11-15 07:50:49

Reaction: Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
Proline hydroxylases PHD1 (EGLN2) and PHD3 (EGLN3) located in the nucleus hydroxylate HIF2A (EPAS1) at proline-405 and proline-531 (Hirsila et al. 2003, Percy et al. 2008, Furlow et al. 2009). The amount of hydroxylation occurring in the nucleus is controversial. Most hydroxylation is believed to be cytosolic
Last changed: 2014-11-21 14:40:22

Reaction: Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located in the cytosol (Metzen et al. 2003) hydroxylate EPAS1 (HIF2A) at proline-405 and proline-531 (Hirsila et al. 2003, Percy et al. 2008, Furlow et al. 2009). A portion of PHD3 (EGLN3) is also located in the nucleus (Rantanen et al. 2008)
Last changed: 2014-11-21 14:40:22

Pathway: Cellular response to hypoxia (Homo sapiens)
Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability
Last changed: 2014-11-21 14:40:22

Pathway: Transcriptional regulation of pluripotent stem cells (Homo sapiens)
Pluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, Player et al. 2006, Wang et al 2006 using mouse, International Stem Cell Initiative 2007, Assou et al. 2007, Assou et al. 2009, Ding et al. 2012 using mouse), and the ability to self-renew and generate all c
Last changed: 2014-11-21 06:36:34

Gene: ENSEMBL:ENSG00000116016 EPAS1 (HIF2A) (Homo sapiens)
Last changed: 2012-12-31 02:50:56

1 2 3 4 5 Next >
Show all results