Reactome: A Curated Pathway Database
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Pathways (8) Reactions (1) Proteins (1) Others (3)
Protein: UniProt:P14867 GABRA1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Neuronal System (Homo sapiens)
The human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication among this astronomical number of elements. This communication occurs across synapses, the functional connection between neurons. Synapses can be divided into two general classes: electrical synapses and che
Last changed: 2015-03-06 23:15:47

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (Homo sapiens)
The neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein coupled receptors that function to transmit the signals from the post-synaptic membrane to the cell body
Last changed: 2015-03-06 23:15:47

Pathway: Ion channel transport (Homo sapiens)
Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemic
Last changed: 2015-03-06 23:15:47

Pathway: Transmission across Chemical Synapses (Homo sapiens)
Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synapti
Last changed: 2015-03-06 23:15:47

Pathway: GABA A receptor activation (Homo sapiens)
GABA B receptors are G protein coupled receptors that are activated by GABA binding to the B1 subunit and B2 subunit alters the activity of adenylate cyclase by interacting with the G alpha i/alpha 0 subunit of the pertussis toxin sensitive G protein. The activation of GABA B receptors results in the inhibition of adenylate cyclase activity decreasing the levels of cyclic AMP production and hence the
Last changed: 2015-03-06 18:40:03

Pathway: GABA receptor activation (Homo sapiens)
Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that ac
Last changed: 2015-03-06 18:40:03

Pathway: Ligand-gated ion channel transport (Homo sapiens)
Ligand-gated ion channels (LGICs) are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (Purves, 2001)
Last changed: 2015-03-06 18:40:03

Reaction: GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
The GABA(A) receptor (GABR) family belongs to the ligand-gated ion channel superfamily (LGIC). Its endogenous ligand is gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. There are six alpha subunits (GABRA) (Garrett et al. 1988, Schofield et al. 1989, Hadingham et al. 1993, Edenberg et al. 2004, Hadingham et al. 1993, Yang et al. 1995, Wingrove et al.
Last changed: 2015-03-06 18:40:03

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