Reactome: A Curated Pathway Database
Results 1 to 10 of 11
Pathways (5) Reactions (2) Proteins (1) Others (3)
Protein: UniProt:Q92908 GATA6 (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2014-11-21 19:49:01

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2014-11-21 19:49:01

Gene: ENSEMBL:ENSG00000141448 GATA6 (Homo sapiens)
Last changed: 2012-12-31 02:50:56

Reaction: POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)
POU5F1 (OCT4) (Boyer et al. 2005) and NANOG (Boyer et al. 2005, Lister et al. 2009) bind the promoter of the GATA6 gene and POU5F1 represses expression (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010). As inferred from mouse GATA6 is required for endoderm differentiatiation where it directly activates Bmp2 expression (Wang et al. 2011, Rong et al. 2012)
Last changed: 2014-02-03 18:32:08

Pathway: Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MK's mature, the polyploid nucleus becomes horseshoe-shap
Last changed: 2014-11-21 19:49:01

Pathway: Transcriptional regulation of pluripotent stem cells (Homo sapiens)
Pluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, Player et al. 2006, Wang et al 2006 using mouse, International Stem Cell Initiative 2007, Assou et al. 2007, Assou et al. 2009, Ding et al. 2012 using mouse), and the ability to self-renew and generate all c
Last changed: 2014-11-21 06:36:34

Pathway: POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (Homo sapiens)
POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al. 2005). About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al. 2005). Upon binding the transcription factors activate expression of one subset of targe
Last changed: 2014-02-03 18:32:08

Reaction: ZFPM proteins bind GATA proteins (Homo sapiens)
The Friend of GATA (FOG) family of proteins are a highly-conserved family of large multitype zinc finger cofactors that bind to the amino zinc finger of GATA transcription factors, modulating their activity. GATA proteins are named for the DNA consensus sequence they recognize, (T/A)GATA(A/G). FOG/GATA protein interactions are essential for the development of many tissues. All six GATA family members a
Last changed: 2014-11-21 06:36:34

Complex: POU5F1:NANOG:GATA6 gene [nucleoplasm] (Homo sapiens)
POU5F1:NANOG:GATA6 gene; OCT4:NANOG:GATA6 gene
Last changed: 2014-01-24 20:21:14

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