Reactome: A Curated Pathway Database
Results 1 to 10 of 38
Pathways (9) Reactions (13) Proteins (1) Others (15)
Protein: UniProt:P13807 GYS1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Disease (Homo sapiens)
Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Glycogen storage diseases (Homo sapiens)
The regulated turnover of glycogen plays a central, tissue-specific role in the maintenance of blood ... ressed form of glycogenin (GSD type XV), GYS2 and GYS1, the liver-specific and ubiquitously expressed forms of glycogen synthase (GSD type 0), GBE1, the single form of branching enzyme (GSD type IV), and in the endoplasmic reticulum-associated phosphatase (G6PC) and transporter (SLC37A4) required fo ...
Last changed: 2015-02-02 16:07:13

Reaction: GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)
Unphosphorylated glycogen synthase 1 (GYS1-a) complexed with oligo-D-glucose-GYG1 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) (Cameron et al. 2009; Roach et al. 2012)
Last changed: 2015-03-06 10:40:16

Reaction: GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)
Glycogen synthase 1 (GYS1) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of phosphate incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (Tagliabracci et al. 2011)
Last changed: 2015-03-06 10:40:16

Reaction: Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)
Phosphorylated glycogen synthase 1 (GYS1-b) complexed with oligo-D-glucose-GYG1 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) This reaction is allosterically activated by glucose-6-phosphate (G6P) (Cameron et al. 2009; Roach et al. 2012)
Last changed: 2015-03-06 10:40:16

Reaction: Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)
Glycogenin 1 (GYG1) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG1 (Moslemi et al. 2010). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS1), here in a phosphorylated (b) form (Roach et al. 2012)
Last changed: 2015-03-06 10:40:16

Reaction: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)
Cytosolic glycogen branching enzyme (GBE1) associated with glycogen granules transfers terminal alpha(1,4) glucose blocks to form alpha(1,6) branches on growing glycogen molecules formed on glycogenin 1 (GYG1) complexed with phosphorylated glycogen synthase 1 (GYS1-b) (Bao et al. 1996; Roach et al. 2012)
Last changed: 2015-03-06 10:40:16

Reaction: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)
Cytosolic glycogen branching enzyme (GBE1) associated with glycogen granules transfers terminal alpha(1,4) glucose blocks to form alpha(1,6) branches on growing glycogen molecules formed on glycogenin 1 (GYG1) complexed with unphosphorylated glycogen synthase 1 (GYS1-a) (Bao et al. 1996; Roach et al. 2012)
Last changed: 2015-03-06 10:40:16

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