Reactome: A Curated Pathway Database
Results 1 to 10 of 147
Pathways (29) Reactions (56) Proteins (2) Others (60)
Pathway: IRAK4 deficiency (TLR5) (Homo sapiens)
Toll like receptor 5 (TLR5) specifically recognizes bacterial infection through binding of flagellin ... ases (IRAKs) to form the Myddosome complex (MyD88:IRAK4:IRAK1/2) (Motshwene PG et al. 2009; Lin SC et al. 2010). The Myddosome complex transmits the signal leading to activation of transcription factors such as nuclear factor-kappaB (NFkB) and activator protein 1 (AP1). Studies have identified patie ...
Last changed: 2015-02-16 22:07:24

Pathway: IRAK4 deficiency (TLR2/4) (Homo sapiens)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase, that mediates activation of transcriptional factors such as NFkB and AP1 downstream of IL-1 receptors and all toll like receptors (TLR) except for TLR3 (Suzuki N et al. 2002). IRAK4 is recruited to the TLR receptor complex through a homophilic interaction of the death domains of IRAK4 and adaptor myeloid differentiation fa
Last changed: 2015-02-16 22:07:24

Protein: UniProt:Q9NWZ3 IRAK4 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Disease (Homo sapiens)
Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally
Last changed: 2015-03-06 23:15:47

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Diseases associated with the TLR signaling cascade (Homo sapiens)
Toll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derive ... defective TLR-mediated responses. First, MyD88 or IRAK4 deficiency is characterized with a greater susceptibility to pyogenic bacteria in affected patients (Picard C et al. 2003; von Bernuth H et al. 2008). Second, defects in the TLR3 signaling pathway are associated with a greater susceptibility to ...
Last changed: 2015-02-19 21:30:08

Pathway: Interleukin-1 signaling (Homo sapiens)
Interleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 rec ... IRAK)-1 and -4, probably via their death domains. IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate. Both IRAK1 and IRAK4 then dissociate from MyD88 (Brikos et al. 2007) which remains stably complexed with IL-1R1 and IL1RAP. They in turn interact with Tumor Necrosis Factor Receptor (TN ...
Last changed: 2015-03-06 18:40:03

Pathway: MyD88 deficiency (TLR5) (Homo sapiens)
Myeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular s ... ases (IRAKs) to form the Myddosome complex (MyD88:IRAK4:IRAK1/2) (Motshwene PG et al. 2009; Lin SC et al. 2010). The Myddosome complex transmits the signal leading to activation of transcription factors such as nuclear factor-kappaB (NFkB) and activator protein 1 (AP1). Studies have identified pat ...
Last changed: 2015-02-16 22:07:24

Pathway: MyD88 deficiency (TLR2/4) (Homo sapiens)
Myeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular s ... ases (IRAKs) to form the Myddosome complex (MyD88:IRAK4:IRAK1/2) (Motshwene PG et al. 2009; Lin SC et al. 2010). The Myddosome complex transmits the signal leading to activation of transcription factors such as nuclear factor-kappaB (NFkB) and activator protein 1 (AP1). Studies have identified pat ...
Last changed: 2015-02-16 22:07:24

Reaction: IRAK4 is activated by autophosphorylation (Homo sapiens)
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346
Last changed: 2015-03-06 10:40:16

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