Reactome: A Curated Pathway Database
Results 1 to 10 of 133
Pathways (22) Reactions (56) Proteins (2) Others (53)
Protein: UniProt:Q9NWZ3 IRAK4 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2014-11-21 19:49:01

Pathway: Interleukin-1 signaling (Homo sapiens)
Interleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 rec ... IRAK)-1 and -4, probably via their death domains. IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate. Both IRAK1 and IRAK4 then dissociate from MyD88 (Brikos et al. 2007) which remains stably complexed with IL-1R1 and IL1RAP. They in turn interact with Tumor Necrosis Factor Receptor (TN ...
Last changed: 2014-11-21 14:40:22

Reaction: IRAK4 is activated by autophosphorylation (Homo sapiens)
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346
Last changed: 2014-11-21 06:36:34

Reaction: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346
Last changed: 2014-11-21 06:36:34

Reaction: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal (Homo sapiens)
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346
Last changed: 2014-11-21 06:36:34

Reaction: IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346
Last changed: 2014-11-21 14:40:22

Reaction: IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll r
Last changed: 2014-08-29 13:41:37

Reaction: IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
A series of sequential phosphorylation events lead to full or hyper-phopshorylation of IRAK1. Under ... activation (Knop & Martin, 1999), unlike that of IRAK4 (Suzuki et al. 2002; Kozicak-Holbro et al. 2007), so IRAK1 is believed to act primarily as an adaptor for TRAF6 (Conze et al. 2008) ...
Last changed: 2014-11-21 06:36:34

Reaction: IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex (Homo sapiens)
IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll r
Last changed: 2014-11-21 06:36:34

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