Reactome: A Curated Pathway Database
Results 1 to 10 of 17
Pathways (6) Reactions (4) Proteins (1) Others (6)
Protein: UniProt:P11226 MBL2 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2014-11-21 19:49:01

Pathway: Complement cascade (Homo sapiens)
In the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cellular debris, healthy and altered host cells (Ricklin D et al. 2010). Complement proteins circulate in the blood stream in functionally inactive states. When triggered the complement cascade generates enzyma
Last changed: 2014-11-21 06:36:34

Pathway: Innate Immune System (Homo sapiens)
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Last changed: 2014-11-21 19:49:01

Pathway: Lectin pathway of complement activation (Homo sapiens)
Mannose-binding lectin (MBL) and ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are Ca-dependent (C-type) lectins, which initiate the complement cascade after binding to specific carbohydrate patterns on the target cell surface. Both MBL and ficolins form oligomers of structural subunits. Each subunit of lectin is composed of three identical polypeptides (Jensen PH et al 2005, Dommett RM et al 2006; Gar
Last changed: 2014-11-21 06:36:34

Pathway: Initial triggering of complement (Homo sapiens)
Complement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by target-bound antibody (the classical pathway); microbial polysaccharide structures (the lectin pathway); or recognition of other "foreign" surface structures (the alternative pathway) by C3b. All three merge
Last changed: 2014-11-21 06:36:34

Pathway: Creation of C4 and C2 activators (Homo sapiens)
Two pathways lead to a complex capable of activating C4 and C2. The classical pathway is triggered by activation of the C1-complex, which consists of hexameric molecule C1q and a tetramer comprising two C1r and two C1s serine proteinases. This occurs when C1q binds to IgM or IgG complexed with antigens, a single IgM can initiate the pathway while multiple IgGs are needed, or when C1q binds direc
Last changed: 2014-11-21 06:36:34

Reaction: Conversion of C2 into C2a and C2b (Homo sapiens)
C2 is cleaved into the large C2a and the small C2b fragment. This irreversible, extracellular reaction can be catalyzed by activated MBL, generated through the lectin pathway of complement activation (Vorup-Jensen et al. 2000), and by activated C1, generated through the classical pathway (Nasagawa and Stroud 1977). N.B. Early literature refers to the larger fragment of C2 as C2a. However, complement sc
Last changed: 2014-11-21 06:36:34

Reaction: MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
The MBL polypeptide chain consists of a short N-terminal cysteine-rich region, a collagen-like region comprising 19 Gly-X-Y triplets, a 34-residue hydrophobic stretch, and a C-terminal C-type lectin domain. MBL monomers associate via their cysteine-rich and collagen-like regions to form homotrimers, and these in turn associate into oligomers. The predominant oligomers found in human serum contain thre
Last changed: 2014-11-21 06:36:34

Reaction: Activation of MASPs (Homo sapiens)
MBL or ficolins binding to carbohydrates on the target surface results in conformational changes in the lectin:MASPs complex. It in turn promotes a cleavage of proenzyme form of MASP between the CCP2 and the serine protease domains, which results in the generation of the active form. The active form of MASP-2 is able to cleave C4 and C2 to generate the C3 convertase (Vorup-Jensen T et al. 2000; Chen CB
Last changed: 2014-11-21 06:36:34

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