Reactome: A Curated Pathway Database
Results 1 to 10 of 21
Pathways (9) Reactions (3) Proteins (6) Others (3)
Protein: UniProt:P30613-1 PKLR (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Protein: UniProt:P30613 PKLR (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Protein: UniProt:P30613-2 PKLR (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2015-03-06 23:15:47

Reaction: HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)
The PKLR gene is transcribed, its mRNA is translated, spliced, and translated to yield the L isoform of PKLR protein. PKLR expression is positively regulated by HNF1A. Mutations in HNF1A are associated with a form of MODY (maturity onset diabetes of the young) (Fanjans et al. 2001) but the molecular details of PKLR expression in intact pancreatic beta cells have not been studied in humans, and are infe
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of carbohydrates (Homo sapiens)
These pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the body (as glycogen) and its mobilization during a short fast; and 3) the synthesis of glucose from pyruvate during extended fasts
Last changed: 2015-03-06 23:15:47

Pathway: Regulation of beta-cell development (Homo sapiens)
The normal development of the pancreas during gestation has been intensively investigated over the past decade especially in the mouse (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). Studies of genetic defects associated with maturity onset diabetes of the young (MODY) has provided direct insight into these processes as they take place in humans (Fajans et al. 2001). During embryogenesis, com
Last changed: 2015-03-06 23:15:47

Pathway: Integration of energy metabolism (Homo sapiens)
Many hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insulin mediates the storage of excess nutrients, glucagon is involved in the mobilization of energy resources in response to low blood glucose levels, principally by stimulating hepatic glucose ou
Last changed: 2015-03-06 23:15:47

Reaction: phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
Cytosolic pyruvate kinase catalyzes the transfer of a high-energy phosphate from phosphoenolpyruvate ... coded by alternatively spliced transcripts of the PKLR gene; isozymes M1 and M2 are encoded by alternatively spliced transcripts of PKM2. In the body, L pyruvate kinase is found in liver (Tani et al. 1988), R in red blood cells (Kanno et al. 1991), M1 in muscle, heart and brain (Takenaka et al. 1991 ...
Last changed: 2015-03-12 13:50:51

1 2 3 Next >
Show all results