Reactome: A Curated Pathway Database
All 10 results
Pathways (5) Reactions (4) Proteins (1) Others (0)
Protein: UniProt:Q96MT3 PRICKLE1 (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Reaction: PRICKLE1 is degraded by the proteasome (Homo sapiens)
Localized degradation of ub-PRICKLE1 contributes to asymmetric localization of the protein (Narimatsu et al, 2009)
Last changed: 2014-11-21 14:40:22

Reaction: SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
PRICKLE1 is a conserved PCP protein with a localization pattern opposite to that of DVL. PRICKLE1 is recruited to the PARD6A:ppDVL2:SMURF complex through its interaction with DVL and is subsequently ubiquitinated by the E3 ligase activity of SMURF (Narimatsu et al, 2009; Jenny et al, 2005). This leads to localized degradation of PRICKLE1, contributing to its asymmetrical localization (Narimatsu et al
Last changed: 2014-11-21 14:40:22

Reaction: WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
Binding of WNT5A to FZD receptors triggers the phosphorylation of DVL2 in the constitutive DVL2:PARD6A complex and is required for the SMURF-mediated degradation of the core PCP protein PRICKLE1 (Narimatsu et al, 2009)
Last changed: 2014-11-21 14:40:22

Pathway: Signaling by Wnt (Homo sapiens)
WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mic
Last changed: 2014-11-21 14:40:22

Pathway: beta-catenin independent WNT signaling (Homo sapiens)
Humans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelial cell line C57MG and to induce secondary axis formation in Xenopus (Wong et al, 1994; Du et al, 1995). So-called canonical WNTs, including Wnt1, 3, 3a and 7, initiate signaling pathways that destabilize t
Last changed: 2014-11-21 14:40:22

Pathway: Asymmetric localization of PCP proteins (Homo sapiens)
One of the hallmarks of the Planar Cell Polarity pathway is the asymmetric distribution of proteins ... Stbm and Pk (homologues to the human VANGL1/2 and PRICKLE1/2/3) colocalize opposite Fz, Dsh and Dgo (FZD, DVL, and ANKRD6, respectively). The two complexes antagonize each other, with Fz:Dsh:Dgo acting to promote signaling downstream of Dsh, while the Stbm:Pk complex restricts this signaling (revie ...
Last changed: 2014-11-21 14:40:22

Reaction: DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
DVL2 is phosphorylated upon WNT5A stimulation of HEK293 cells. In human mammary carcinoma cells, DVL2 has been shown to be constititutively bound to PARD6A, irrespective of WNT stimulation and DVL phosphorylation (Narimatsu et al, 2009). PARD6A is a partitioning protein with known roles in the establishment of apico-basal polarity (reviewed in Chen and Zhang, 2013). More recently, PARD6A and the S
Last changed: 2014-02-04 16:07:01

Pathway: PCP/CE pathway (Homo sapiens)
The planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement of hair bristles and photoreceptors in the eye (reviewed in Maung and Jenny, 2011). In vertebrates, PCP regulates convergent extension (CE, a process by which a tissue narrows along one axis and lengthens al
Last changed: 2014-11-21 14:40:22