Reactome: A Curated Pathway Database
All 8 results
Pathways (3) Reactions (2) Proteins (1) Others (2)
Protein: UniProt:P37088 SCNN1A (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: Ion channel transport (Homo sapiens)
Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemic
Last changed: 2014-11-21 19:49:01

Pathway: Stimuli-sensing channels (Homo sapiens)
Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2
Last changed: 2014-11-21 19:49:01

Reaction: SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)
Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epithelial Na+ channels, non voltage-gated sodium channels) belong to the epithelial Na+ channel/degenerin (ENaC/DEG) protein family and mediate the transport of Na+ (and associated water) through the apical membrane of epithelial cells in kidney, colon and lungs. This makes SCNNs important determinants of systemic blood pressure. The physiological
Last changed: 2014-11-21 03:10:46

Reaction: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epithelial Na+ channels, non voltage-gated sodium channels) comprises three subunits (alpha, beta and gamma) and plays an essential role in Na+ and fluid absorption in the kidney, colon and lung. The number of channels at the cell's surface (consequently its function) can be regulated. This is achieved by ubiquitination of SCNN via E3 ubiquitin-pro
Last changed: 2014-11-21 03:10:46

Complex: SCNN channels [plasma membrane] (Homo sapiens)
SCNN channels; SCNN (alpha/delta:beta:gamma)
Last changed: 2013-01-02 13:42:00

Complex: Ub-SCNN channels [plasma membrane] (Homo sapiens)
Ub-SCNN channels; SCNN (Ub-alpha/delta:beta:Ub-gamma)
Last changed: 2013-01-02 13:42:00