Reactome: A Curated Pathway Database
Results 1 to 10 of 18
Pathways (6) Reactions (5) Proteins (2) Others (5)
Protein: UniProt:O15273 TCAP (Homo sapiens)
Last changed: 2014-11-25 20:54:06

Pathway: Muscle contraction (Homo sapiens)
In this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated
Last changed: 2014-11-21 19:49:01

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2014-11-21 19:49:01

Pathway: Platelet activation, signaling and aggregation (Homo sapiens)
Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the platelet membrane (Ruggeri 2002). Intracellular signaling reactions then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. Once platelets have
Last changed: 2014-11-21 19:49:01

Pathway: Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platel
Last changed: 2014-11-21 19:49:01

Pathway: Striated Muscle Contraction (Homo sapiens)
Striated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of musc
Last changed: 2014-11-21 06:36:34

Pathway: Platelet degranulation (Homo sapiens)
Platelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules, dense granules and lysosomes. On activation platelets release a variety of proteins, largely from storage granules but also as the result of apparent cell lysis. These act in an autocrine or paracrine fas
Last changed: 2014-11-21 19:49:01

Reaction: Myosin Binds ATP (Homo sapiens)
A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament
Last changed: 2014-11-21 06:36:34

Reaction: Release Of ADP From Myosin (Homo sapiens)
The weak binding of the myosin head to the new site on the actin filament causes release of the inorganic phosphate produced by ATP hydrolysis, concomitantly with the tight binding of the head to actin. This release triggers the power stroke, a force-generating change in the shape during which the head regains its original conformation. In the course of the power stroke, the head loses its bound ADP, t
Last changed: 2014-11-21 06:36:34

Reaction: Calcium Binds Troponin-C (Homo sapiens)
At the start of the cycle a myosin head lacking a bound nucleotide is locked tightly onto an actin filament in a rigor conformation. Troponin-C has bound four calcium ions. In an actively contracting muscle this state is very short-lived, being rapidly terminated by the binding of a molecule of ATP
Last changed: 2014-11-21 06:36:34

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