Reactome: A Curated Pathway Database
Results 1 to 10 of 28
Pathways (6) Reactions (9) Proteins (2) Others (11)
Protein: UniProt:P09493 TPM1 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Muscle contraction (Homo sapiens)
In this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated
Last changed: 2014-11-21 19:49:01

Pathway: Programmed Cell Death (Homo sapiens)
Cell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number of different forms of cell death, each with a corresponding number of complex subprocesses. The first form of regulated or programmed cell death to be characterized was apoptosis. Evidence has emerged for a
Last changed: 2014-11-21 19:49:01

Pathway: Extrinsic Pathway (Homo sapiens)
Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the ac
Last changed: 2014-11-21 14:40:22

Pathway: Role of DCC in regulating apoptosis (Homo sapiens)
In the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC and the interaction of caspase-9. Recent reports have shown that UNC5 receptors similarly induce apoptosis in the absence of Netrin-1. These reactions proceed without a requirement for cytochrome c release
Last changed: 2014-11-21 14:40:22

Pathway: Smooth Muscle Contraction (Homo sapiens)
Layers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac muscle. Smooth muscle is triggered to contract by the autonomic nervous system, hormones, autocrine/paracrine agents, local chemical signals, and changes in load or length. Actin:myosin cross bridging i
Last changed: 2014-11-21 19:49:01

Pathway: Striated Muscle Contraction (Homo sapiens)
Striated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of musc
Last changed: 2014-11-21 06:36:34

Reaction: Myosin Binds ATP (Homo sapiens)
A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament
Last changed: 2014-11-21 06:36:34

Reaction: Myosin Binds ATP (Homo sapiens)
With the expulsion of ADP from the nucleotide binding pocket, ATP, if available will immediately bind
Last changed: 2014-11-21 06:36:34

Reaction: Calcium Binds Caldesmon (Homo sapiens)
Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding
Last changed: 2014-11-21 06:36:34

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