Reactome: A Curated Pathway Database
All 10 results
Pathways (3) Reactions (3) Proteins (1) Others (3)
Protein: UniProt:Q96QK1 VPS35 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2015-03-06 23:15:47

Pathway: Signaling by Wnt (Homo sapiens)
WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mic
Last changed: 2015-03-06 18:40:03

Pathway: WNT ligand biogenesis and trafficking (Homo sapiens)
19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases.
Last changed: 2015-03-06 18:40:03

Reaction: Retromer associates with WLS (Homo sapiens)
Retromer is a conserved multi-protein complex that is required for retrograde transport of transmemb ... ists of a cargo-recognition subcomplex made up of VPS35, VPS26 and VPS29 and a membrane-targeting subcomplex containing a heterodimer of SNX proteins (SNX1 or 2 paired with SNX5 or 6). The SNX proteins contain a BAR domain that is believed to promote membrane curvature, and SNX-BAR proteins are tho ...
Last changed: 2015-03-06 10:40:16

Reaction: Retromer recycles WLS to the Golgi (Homo sapiens)
Retromer is believed to escort WLS from the early endosome back to the Golgi for subsequent rounds of WNT secretion (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012 )
Last changed: 2015-03-06 18:40:03

Reaction: WLS dissociates from retromer (Homo sapiens)
Although the role of retromer in delivering WLS back to the Golgi is reasonably well established (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012), the details of how the complex is disassembled at the TGN remain to be determined
Last changed: 2015-03-06 10:40:16

Complex: VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35:VPS29:VPS26; retromer subcomplex
Last changed: 2013-04-05 20:03:13

Complex: WLS:retromer [early endosome membrane] (Homo sapiens)
Last changed: 2013-04-05 20:05:15

Complex: WLS:retromer [Golgi membrane] (Homo sapiens)
Last changed: 2013-04-05 20:05:15