Reactome: A Curated Pathway Database
All 7 results
Pathways (4) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:O14949 UQCRQ (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2014-11-21 19:49:01

Pathway: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling p
Last changed: 2014-11-21 19:49:01

Pathway: The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to
Last changed: 2014-11-21 19:49:01

Pathway: Respiratory electron transport (Homo sapiens)
Mitochondria are often described as the "powerhouse" of a cell as it is here that energy is largely released from the oxidation of food. Reducing equivalents generated from beta-oxidation of fatty acids and from the Krebs cycle enter the electron transport chain (also called the respiratory chain ). During a series of redox reactions, electrons travel down the chain releasing
Last changed: 2014-11-21 19:49:01

Reaction: Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
The Protonmotive Q cycle is the mechanism by which complex III transfers electrons from ubiquinol to cytochrome c, linking this process to translocation of protons across the membrane. This cycle is complicated by the fact that both ubiquinol is oxidised and ubiquinone is reduced during this process. Through a complex series of electron transfers, Complex III consumes two molecules of ubi
Last changed: 2014-11-21 14:40:22

Complex: Ubiquinol-cytochrome c reductase [mitochondrial inner membrane] (Homo sapiens)
Ubiquinol-cytochrome c reductase; cytochrome b-c1 complex; Complex III
Last changed: 2014-11-25 17:55:37