Reactome: A Curated Pathway Database
All 6 results
Pathways (2) Reactions (2) Proteins (1) Others (1)
Protein: UniProt:O15360 FANCA (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: DNA Repair (Homo sapiens)
DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair adducts that arise. DNA damage can arise spontaneously in the cellular milieu through chemical alteration of base nucleotides or as a consequence of errors during DNA replication. For example, it is well k
Last changed: 2015-03-06 23:15:47

Pathway: Fanconi Anemia pathway (Homo sapiens)
Fanconi anemia (FA) is a genetic disease of genome instability characterized by congenital skeletal defects, aplastic anemia, susceptibility to leukemias, and cellular sensitivity to DNA damaging agents. Patients with FA have been categorized into at least 13 complementation groups (FA-A, -B, -C, -D1, -D2, -E, -F, -G, -I, -J, -L, -M, and -N). These complementation groups correspond to the genes FANCA,
Last changed: 2015-03-06 23:15:47

Reaction: Monoubiquitination of FANCI by the FA ubiquitin ligase complex (Homo sapiens)
FANCI is monoubiquitinated on lysine 523 in an FA core-complex-dependent manner (Sims et al., 2007; Smogorzewska et al. 2007). FANCD2 and FANCI are mutually dependent on each other for their respective monoubiquitination. However, multiple phosphorylation of FANCI but not monoubiquitination is crucial for FANCD2 activation following DNA damage (Ishiai et al., 2008)
Last changed: 2015-03-06 10:40:16

Reaction: Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex (Homo sapiens)
Lysine 561 of FANCD2 is monoubiquitinated by FANCL, a component of the FA core complex with ubiquitin ligase activity (Garcia Higuera et al., 2001). UBE2T binds to FANCL, and is required for the monoubiquitination of FANCD2 (Machida et al., 2006). Monoubiquitination of FANCD2 in turn is necessary for its localization to chromatin and for the formation of nuclear foci in response to DNA damage. FANCD2
Last changed: 2015-03-06 10:40:16

Complex: FA core complex [nucleoplasm] (Homo sapiens)
FA core complex
Last changed: 2009-05-21 23:59:11