Reactome: A Curated Pathway Database
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Pathways (4) Reactions (3) Proteins (1) Others (4)
Protein: UniProt:P00846 MT-ATP6 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling p
Last changed: 2015-03-06 23:15:47

Pathway: The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to
Last changed: 2015-03-06 23:15:47

Pathway: Formation of ATP by chemiosmotic coupling (Homo sapiens)
The re-entry of protons into the mitochondrial matrix through Complex V causes conformational changes which result in ATP synthesis. Complex V (ATP synthase) is composed of 3 parts; an F1 catalytic core (approx 5 subunits), an F0 membrane proton channel (approx 9 subunits) and two stalks linking F1 to F0. F1 contains three alpha subunits, three beta subunits, and one each of gamma, delta, and epsilon s
Last changed: 2015-03-06 18:40:03

Reaction: ATP is synthesized from ADP and Pi by ATPase (Homo sapiens)
In the tight configuration, the beta subunit catalyzes the reaction of ADP + Pi to ATP + water. ATP is still tightly bound to the subunit at this stage
Last changed: 2015-03-06 18:40:03

Reaction: ADP and Pi bind to ATPase (Homo sapiens)
The beta subunit has 3 conformations; tight , open and loose . ADP and Pi bind to the subunit in the loose form. On binding, this subunit is converted to the tight configuration
Last changed: 2015-03-06 18:40:03

Reaction: Enzyme-bound ATP is released (Homo sapiens)
In the last step, the beta subunit is converted to the open form and ATP is released. Passage of protons through the Fo part causes a ring of approximately 10 subunits to rotate. This rotation in turn drives the rotation of the gamma subunits, which forms part of one of the stalks. The gamma subunit moves between the three beta subunits which are held in place by the second stalk which can be regarded
Last changed: 2015-03-06 18:40:03

Complex: ATPase-ATP complex [mitochondrial inner membrane] (Homo sapiens)
ATPase-ATP complex
Last changed: 2010-01-27 10:02:10

Complex: ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
ATPase CF(0)
Last changed: 2014-02-05 11:39:56

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