Reactome: A Curated Pathway Database
Results 1 to 10 of 18
Pathways (4) Reactions (5) Proteins (1) Others (8)
Protein: UniProt:P01375 TNF (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Programmed Cell Death (Homo sapiens)
Cell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number of different forms of cell death, each with a corresponding number of complex subprocesses. The first form of regulated or programmed cell death to be characterized was apoptosis. Evidence has emerged for a
Last changed: 2014-11-21 19:49:01

Pathway: Death Receptor Signalling (Homo sapiens)
The death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif found on all of the three receptors (FAS/CD95, TNF-receptor, and TRAIL-receptor) that binds the Fas-associated protein with death domain (FADD). Ligand binding to death receptors (DR) results in receptor o
Last changed: 2014-11-21 06:36:34

Pathway: Extrinsic Pathway (Homo sapiens)
Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the ac
Last changed: 2014-11-21 14:40:22

Pathway: TNF signaling (Homo sapiens)
The Tumor Necrosis Factor alpha (TNF-alpha) mediated apoptosis pathway has been implicated in the pathogenesis of a number of diseases including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The TNF signaling network provides extensive cross talk between the apoptotic pathway, and the other NF-B, and JNK pathways that also emanate fro
Last changed: 2014-11-21 06:36:34

Reaction: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Homo sapiens)
Once formed the TRADD:TRAF2:RIP1 complex may dissociate from the TNF:TNF-R1 platform and become cytosolic. If this complex recruits FADD then the cell will be pushed along the apoptotic pathway
Last changed: 2014-11-21 06:36:34

Reaction: Membrane-anchored TNF-alpha binds TNF-R1 (Homo sapiens)
Transmembrane TNF-alpha (tmTNF-alpha), a precursor of the soluble form of TNF-alpha, is expressed in macrophages and lymphocytes as well as other cell types, tmTNF-alpha functions as a bipolar molecule that can transmit signals both as a ligand and as a receptor in a cell-to-cell contact fashion. Transmembrane TNF-alpha on TNF-alpha-producing cells binds to TNF-R1 and -R2, and transmits signals to the
Last changed: 2014-11-21 06:36:34

Reaction: TNF-alpha cleavage by TACE (Homo sapiens)
TNF-alpha is initially synthesized as a 26kDa transmembrane precursor (pro-TNF-alpha), which is processed by proteolytic cleavage known as ectodomain shedding (Tang P et al. 1996). TNF-alpha-converting enzyme (TACE or ADAM17) has been shown to mediate the cleavage of TNF-alpha generating the soluble 17kDa mature form (Robertshaw HJ & Brennan FM 2005). Inhibition of TACE activity resulted in an accumula
Last changed: 2014-11-21 06:36:34

Reaction: Soluble TNF-alpha binds TNF-R1 (Homo sapiens)
Soluble form of TNF-alpha is cleaved from membrane-anchored TNF-alpha and bind to TNF receptors (TNF-R1 and -R2)
Last changed: 2014-11-21 06:36:34

Reaction: TNF:TNF-R1 binds TRADD, TRAF2 and RIP (Homo sapiens)
Once the TNF-aplha:TNF-R1:TRADD complex is formed the two TNF-alpha mediated pathways are possible. The variable is the recruitment of FADD to the larger complex formed by the TNF-aplha:TNF-R1 platform via the interaction of the Death Domains. The steps leading to the Jun, NF kappaB, or apoptotic pathways are rife with modulation
Last changed: 2014-11-21 06:36:34

1 2 Next >
Show all results