Reactome: A Curated Pathway Database
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Pathways (9) Reactions (4) Proteins (1) Others (6)
Protein: UniProt:P02792 FTL (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Vesicle-mediated transport (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Membrane Trafficking (Homo sapiens)
The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport
Last changed: 2015-03-06 23:15:47

Pathway: Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). Some scavenger receptors, such as the CD163-haptoglobin system, are specific for only one ligand. Others, such as the SCARA receptors (SR-A receptors) are less specific, binding several ligands which share a
Last changed: 2015-03-06 18:40:03

Pathway: Iron uptake and transport (Homo sapiens)
The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur cluste
Last changed: 2015-03-06 23:15:47

Pathway: trans-Golgi Network Vesicle Budding (Homo sapiens)
After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane
Last changed: 2015-03-06 23:15:47

Pathway: Clathrin derived vesicle budding (Homo sapiens)
There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane ass
Last changed: 2015-03-06 23:15:47

Pathway: Golgi Associated Vesicle Biogenesis (Homo sapiens)
Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes
Last changed: 2015-03-06 18:40:03

Pathway: Scavenging by Class A Receptors (Homo sapiens)
Class A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009, Bowdish and Gordon 2009). The coiled coil domains interact to form trimers. The collagenous domain (Rohrer et al. 1990, Acton et al. 1993) and/or the SR cysteine-rich domain (Brannstrom et al. 2002) bind
Last changed: 2015-03-06 10:40:16

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