Reactome: A Curated Pathway Database
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Pathways (6) Reactions (2) Proteins (1) Others (5)
Protein: UniProt:P03372 ESR1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Gene Expression (Homo sapiens)
Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are
Last changed: 2015-03-06 23:15:47

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2015-03-06 23:15:47

Pathway: Generic Transcription Pathway (Homo sapiens)
OVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or tissue-specific regulation of differential gene transcription is mediated (reviewed in Naar, 2001. Kadonaga, 2004, Maston, 2006, Barolo, 2002; Roeder, 2005, Rosenfeld, 2006). Of the three maj
Last changed: 2015-03-06 23:15:47

Pathway: Signaling by ERBB4 (Homo sapiens)
ERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular ligand binding domain, a single transmembrane domain and a cytoplasmic domain which contains an active tyrosine kinase and a C-tail with multiple phosphorylation sites. At least three and possibly four splicin
Last changed: 2015-03-06 23:15:47

Pathway: Nuclear Receptor transcription pathway (Homo sapiens)
A classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other small, diffusible signaling molecules. The non-liganded NRs recruit specific corepressor complexes of the NCOR/SMRT type, to mediate transcriptional repression of the target genes to which they are bound.
Last changed: 2015-03-06 18:40:03

Pathway: Nuclear signaling by ERBB4 (Homo sapiens)
Besides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembrane region, resulting in shedding of the extracellular domain and formation of an 80 kDa membrane bound ERBB4 fragment known as ERBB4 m80 (Rio et al. 2000, Cheng et al. 2003). ERBB4 m80 undergoes further pr
Last changed: 2015-03-06 18:40:03

Reaction: Formation of NR-MED1 Coactivator Complex (Homo sapiens)
THE NUCLEAR RECEPTOR-MED1 REACTION : The Nuclear Receptor (NR) proteins are a highly conserved family of DNA-binding transcription factors that bind certain hormones, vitamins, and other small, diffusible signaling molecules. The non-liganded NRs recruit specific corepressor complexes of the NCOR/SMRT type, to mediate transcriptional repression of the target genes to which they are bound. During
Last changed: 2015-03-06 18:40:03

Reaction: ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)
ERBB4s80 forms a complex with activated estrogen receptor ESR1 in the nucleus and acts as a transcriptional co-factor for ESR1
Last changed: 2015-03-06 10:40:16

Activation: 'ERBB4s80:ESR1 [nucleoplasm]' positively regulates 'Transcription of NR3C3 and CXCL12'
ERBB4s80:ESR1 complex regulates transcription of NR3C3 and CXCL12
Last changed: 2011-04-29 17:16:06

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