Reactome: A Curated Pathway Database
Results 1 to 10 of 73
Pathways (14) Reactions (25) Proteins (1) Others (33)
Protein: UniProt:P04222 HLA-C (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Class I MHC mediated antigen processing & presentation (Homo sapiens)
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells th
Last changed: 2015-03-06 23:15:47

Pathway: Cytokine Signaling in Immune system (Homo sapiens)
Cytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concentrations. Cytokines bind to specific membrane receptors, which then signal the cell via second messengers, to regulate cellular activity
Last changed: 2015-03-06 23:15:47

Pathway: DAP12 interactions (Homo sapiens)
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in t
Last changed: 2015-03-06 23:15:47

Pathway: Interferon gamma signaling (Homo sapiens)
Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by interacting with the specific IFN-gamma receptor (IFNGR). IFNGR consists of two chains, namely IFNGR1 (also known as the IFNGR alpha chain) and IFNGR2 (also known as the IFNGR beta chain). IFNGR1 is the lig
Last changed: 2015-03-06 10:40:16

Pathway: Interferon Signaling (Homo sapiens)
Interferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others, such as omega, epsilon, and kappa), Type II (IFN-gamma) and Type III (IFN-lamda). In this module we are mainly focusing on type I IFNs alpha and beta and type II IFN-gamma. Both type I and type II IFNs ex
Last changed: 2015-03-06 23:15:47

Pathway: Innate Immune System (Homo sapiens)
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Last changed: 2015-03-06 23:15:47

Pathway: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation.
Last changed: 2015-03-06 10:40:16

Pathway: Interferon alpha/beta signaling (Homo sapiens)
Type I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, whereas there is only one IFNB gene. The large family of IFNA/B proteins all bind to a single receptor which is composed of two distinct chains: IFNAR1 and IFNAR2. The IFNA/B stimulation of the IFNA receptor co
Last changed: 2015-03-06 10:40:16

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