Reactome: A Curated Pathway Database
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Pathways (10) Reactions (8) Proteins (1) Others (8)
Protein: UniProt:P06748 NPM1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Disease (Homo sapiens)
Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally
Last changed: 2015-03-06 23:15:47

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Nucleosome assembly (Homo sapiens)
The formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A)
Last changed: 2015-03-06 10:40:16

Pathway: Host Interactions of HIV factors (Homo sapiens)
Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein
Last changed: 2015-02-06 15:04:48

Pathway: HIV Infection (Homo sapiens)
The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion wi
Last changed: 2015-02-06 15:02:46

Pathway: Chromosome Maintenance (Homo sapiens)
Chromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here
Last changed: 2015-03-06 23:15:47

Pathway: Infectious disease (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
Eukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophase/early G1 phase of the cell cycle. Once deposited, nucleosomes containing CENPA remain stably associated with the centromere and are partitioned equally to daughter centromeres during S phase. A current mo
Last changed: 2015-03-06 10:40:16

Pathway: Interactions of Rev with host cellular proteins (Homo sapiens)
In order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nuclear import appears to be achieved by the association of Rev with importin-beta and B23 and docking at the nuclear pore through interactions between importin-beta and nucleoporins. The dissociation of Rev wi
Last changed: 2014-12-12 21:43:37

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