Reactome: A Curated Pathway Database
Results 1 to 10 of 11
Pathways (4) Reactions (2) Proteins (1) Others (4)
Protein: UniProt:P07195 LDHB (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to
Last changed: 2015-03-06 23:15:47

Pathway: Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Pyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the reversible oxidation of lactate or transamination of alanine, can be converted to acetyl CoA. Other sources of acetyl CoA include breakdown of free fatty acids and ketone bodies in the fasting state. Acetyl
Last changed: 2015-03-06 23:15:47

Pathway: Pyruvate metabolism (Homo sapiens)
Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanine. It can be converted by the pyruvate dehydrogenase complex to acetyl CoA (Reed and Hackert 1990) which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, s
Last changed: 2015-03-06 23:15:47

Reaction: Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+ (Homo sapiens)
Cytosolic lactate dehydrogenase catalyzes the reversible reaction of pyruvate and NADH + H+ to form lactate and NAD+. In the body under anaerobic conditions such as are found in red blood cells or rapidly exercising skeletal muscle, this reaction regenerates NAD+, allowing the continuation of glycolysis. Lactate dehydrogenase is active as a tetramer. Two isoforms of lactate dehydrogenase, A and B, a
Last changed: 2015-03-06 23:15:47

Reaction: (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+ (Homo sapiens)
Cytosolic lactate dehydrogenase catalyzes the freely reversible reaction of lactate and NAD+ to form pyruvate and NADH + H+. In liver parenchymal cells, this reaction allows lactate from red blood cells and exercising muscle to be converted to pyruvate which in turn is typically used for gluconeogenesis which also consumes the NADH from the reaction. Lactate dehydrogenase is active as a tetramer. Two
Last changed: 2015-03-12 13:50:51

Complex: lactate dehydrogenase A3B complex [cytosol] (Homo sapiens)
lactate dehydrogenase A3B complex
Last changed: 2015-02-25 23:11:25

Complex: LDHB tetramer [cytosol] (Homo sapiens)
LDHB tetramer; lactate dehydrogenase B4 complex
Last changed: 2014-11-20 09:17:44

Complex: lactate dehydrogenase A2B2 complex [cytosol] (Homo sapiens)
lactate dehydrogenase A2B2 complex
Last changed: 2015-02-25 23:11:25

1 2 Next >
Show all results