Reactome: A Curated Pathway Database
Results 1 to 10 of 15
Pathways (7) Reactions (7) Proteins (1) Others (0)
Protein: UniProt:P07477 PRSS1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Extracellular matrix organization (Homo sapiens)
The extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded in a viscoelastic gel of anionic proteoglycan polymers. It performs many functions in addition to its structural role; as a major component of the cellular microenvironment it influences cell behaviours su
Last changed: 2015-03-06 18:40:03

Pathway: Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include ma
Last changed: 2015-03-06 23:15:47

Pathway: Activation of Matrix Metalloproteinases (Homo sapiens)
The matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput proteomics analyses have revealed that ~80% of MMP substrates are non-ECM proteins including cytokines, growth factor binding protiens, and receptors. It is now clear that MMPs regulate ECM turnover not only b
Last changed: 2015-03-06 10:40:16

Pathway: Metabolism of vitamins and cofactors (Homo sapiens)
Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include ma
Last changed: 2015-03-06 23:15:47

Pathway: Degradation of the extracellular matrix (Homo sapiens)
Matrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the metzincin family. They contain a characteristic zinc-binding motif HEXXHXXGXXH (Stocker & Bode 1995) and a conserved Methionine which forms a Met-turn. Humans have 24 MMP genes giving rise to 23 MMP protei
Last changed: 2015-03-06 18:40:03

Pathway: Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Vitamin B 12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating with a cobalt atom through four nitrogen atoms. A 5,6-dimethylbenzamidizole base coordinates with the cobalt atom in the lower axial position while a number of different species can coordinate with
Last changed: 2015-03-06 18:40:03

Reaction: Pancreatic proteases degrade TCN1:Cbl (Homo sapiens)
In the proximal intestine, pancreatic enzymes degrade transcobalamin 1 (TCN1) to release cobalamin (Cbl). The two major pancreatic proteases are trypsins (PRSSs) and chymotrypsins (CTRBs) (Srikumar & Premalatha 2003, Nielsen et al. 2012)
Last changed: 2015-03-05 18:55:25

Reaction: Activation of proMMP10 (Homo sapiens)
proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin
Last changed: 2015-03-06 10:40:16

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