Reactome: A Curated Pathway Database
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Pathways (3) Reactions (8) Proteins (1) Others (10)
Protein: UniProt:P09493 TPM1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Muscle contraction (Homo sapiens)
In this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated
Last changed: 2015-03-06 23:15:47

Pathway: Smooth Muscle Contraction (Homo sapiens)
Layers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac muscle. Smooth muscle is triggered to contract by the autonomic nervous system, hormones, autocrine/paracrine agents, local chemical signals, and changes in load or length. Actin:myosin cross bridging i
Last changed: 2015-03-06 23:15:47

Pathway: Striated Muscle Contraction (Homo sapiens)
Striated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of musc
Last changed: 2015-03-06 10:40:16

Reaction: Myosin Binds ATP (Homo sapiens)
A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament
Last changed: 2015-03-06 10:40:16

Reaction: Myosin Binds ATP (Homo sapiens)
With the expulsion of ADP from the nucleotide binding pocket, ATP, if available will immediately bind
Last changed: 2015-03-06 10:40:16

Reaction: Calcium Binds Caldesmon (Homo sapiens)
Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding
Last changed: 2015-03-06 10:40:16

Reaction: Release Of ADP From Myosin (Homo sapiens)
The weak binding of the myosin head to the new site on the actin filament causes release of the inorganic phosphate produced by ATP hydrolysis, concomitantly with the tight binding of the head to actin. This release triggers the power stroke, a force-generating change in the shape during which the head regains its original conformation. In the course of the power stroke, the head loses its bound ADP, t
Last changed: 2015-03-06 10:40:16

Reaction: Calcium Binds Troponin-C (Homo sapiens)
At the start of the cycle a myosin head lacking a bound nucleotide is locked tightly onto an actin filament in a rigor conformation. Troponin-C has bound four calcium ions. In an actively contracting muscle this state is very short-lived, being rapidly terminated by the binding of a molecule of ATP
Last changed: 2015-03-06 10:40:16

Reaction: ATP Hydrolysis By Myosin (Homo sapiens)
The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein
Last changed: 2015-03-06 10:40:16

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