Reactome: A Curated Pathway Database
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Pathways (7) Reactions (3) Proteins (1) Others (4)
Protein: UniProt:P10276 RARA (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Gene Expression (Homo sapiens)
Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are
Last changed: 2014-11-21 19:49:01

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Pathway: Generic Transcription Pathway (Homo sapiens)
OVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or tissue-specific regulation of differential gene transcription is mediated (reviewed in Naar, 2001. Kadonaga, 2004, Maston, 2006, Barolo, 2002; Roeder, 2005, Rosenfeld, 2006). Of the three maj
Last changed: 2014-11-21 14:40:22

Pathway: Orphan transporters (Homo sapiens)
This section contains known or putative transporters that are either directly involved in a transport process or, through their binding to other proteins, assist in a transport process (Purves 2001, He et al. 2009, Rees et al. 2009)
Last changed: 2014-11-21 19:49:01

Pathway: Signaling by Retinoic Acid (Homo sapiens)
Vitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. Genes regulated by retinoids are essential for reproduction, embryonic development, growth, and multiple processes in the adult, including energy balance, neurogenesis, and the immune response. The retinoid
Last changed: 2014-11-21 19:49:01

Pathway: Nuclear Receptor transcription pathway (Homo sapiens)
A classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other small, diffusible signaling molecules. The non-liganded NRs recruit specific corepressor complexes of the NCOR/SMRT type, to mediate transcriptional repression of the target genes to which they are bound.
Last changed: 2014-11-21 14:40:22

Reaction: Formation of NR-MED1 Coactivator Complex (Homo sapiens)
THE NUCLEAR RECEPTOR-MED1 REACTION : The Nuclear Receptor (NR) proteins are a highly conserved family of DNA-binding transcription factors that bind certain hormones, vitamins, and other small, diffusible signaling molecules. The non-liganded NRs recruit specific corepressor complexes of the NCOR/SMRT type, to mediate transcriptional repression of the target genes to which they are bound. During
Last changed: 2014-11-21 14:40:22

Reaction: RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)
In the nucleus, cellular retinoic acid binding protein 2 (CRABP2), bound to all trans retinoic acid (atRA), directly binds to heterodimeric nuclear retinoic acid receptors (RAR:RXR) to form a complex through which atRA is channeled from the binding protein to RAR (Majumdar et al. 2011). The RAR:RXR heterodimer can be formed between any of three receptor isoforms for each; RARA, RARB, or RARG with RXRA,
Last changed: 2014-11-21 06:36:34

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