Reactome: A Curated Pathway Database
Results 1 to 10 of 29
Pathways (5) Reactions (10) Proteins (1) Others (13)
Protein: UniProt:P11277 SPTB (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2015-03-06 23:15:47

Pathway: Axon guidance (Homo sapiens)
Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the
Last changed: 2015-03-06 23:15:47

Pathway: L1CAM interactions (Homo sapiens)
The L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L1 (CHL1), NrCAM, and Neurofascin. These CAMs contain six Ig like domains, five or six fibronectin like repeats, a transmembrane region and a cytoplasmic domain. The L1CAM family has been implicated in proce
Last changed: 2015-03-06 23:15:47

Pathway: NCAM signaling for neurite out-growth (Homo sapiens)
The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. The role of NCAM in neural differentiation and synaptic plasticity is presumed to depend on the modulation of intracellular signal transduction cascades. NCAM based signaling complexes can in
Last changed: 2015-03-06 23:15:47

Pathway: Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by three genes (ankyrin-G, -B and -R) of which ankyrin-G and -B are the major forms expressed in the developing nervous system. Ankyrins bind to the cytoplasmic domain of L1 CAMs and couple them and ion channel
Last changed: 2015-03-06 10:40:16

Reaction: Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
Phosphorylated tyrosine 925 in the FAT domain of FADK1 creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. FADK1 may use this mechanism to activate Ras and the MAP kinase pathway
Last changed: 2015-03-06 18:40:03

Reaction: L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
Ankyrins are bifunctional linker proteins that tether L1 to the membrane associated, spectrin based actin cytoskeleton. Spectrin is a tetramer of two alpha- and two beta-chains. The spectrin alpha chain has 21 and the beta chain has 16 (conventional beta) or 30 (heavy beta) successive triple helix repeats. At the N-terminus of beta spectrin, there is a pair of CH (calponin homology) domains which toge
Last changed: 2015-03-06 10:40:16

Reaction: Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
Ankyrins link both L1 and ion channel proteins, coupling them to the spectrin actin cytoskeleton. In the nervous system ankyrins interact with voltage gated channels and cluster them in axon initial segments to generate action potentials. At these points the actin spectrin network is linked via ankyrins to voltage gated sodium channels, L1, and the voltage gated potassium ion channel subunits, KCNQ2 an
Last changed: 2015-03-06 10:40:16

Reaction: Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
The homophilic NCAM1:NCAM1 interaction redistributes these molecules and leads to the formation of clusters within lipid rafts. Spectrin, an NCAM1 binding cytoskeletal protein, colocalizes with NCAM1 and codistribute to lipid rafts. Spectrin associates with RPTP-alpha, linking it to the cytoplasmic NCAM1 domain and causing its coredistribution to lipid rafts on NCAM1 clustering. The receptor tyrosine p
Last changed: 2015-03-06 18:40:03

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