Reactome: A Curated Pathway Database
Results 1 to 10 of 17
Pathways (4) Reactions (5) Proteins (1) Others (7)
Protein: UniProt:P16871 IL7R (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Interleukin-7 signaling (Homo sapiens)
Interleukin-7 (IL7) is produced primarily by T zone fibroblastic reticular cells found in lymphoid organs, and also expressed by non-hematopoietic stromal cells present in other tissues including the skin, intestine and liver. It is an essential survival factor for lymphocytes, playing a key anti-apoptotic role in T-cell development, as well as mediating peripheral T-cell maintenance and proliferation.
Last changed: 2015-03-06 18:40:03

Pathway: Cytokine Signaling in Immune system (Homo sapiens)
Cytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concentrations. Cytokines bind to specific membrane receptors, which then signal the cell via second messengers, to regulate cellular activity
Last changed: 2015-03-06 23:15:47

Pathway: Signaling by Interleukins (Homo sapiens)
Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis,
Last changed: 2015-03-06 23:15:47

Reaction: Interleukin-7:IL7RA:JAK1 binds Gc:JAK3 (Homo sapiens)
Studies using chemical crosslinking and monoclonal antibodies specific for the IL-2 receptor gamma chain (Gc) demonstrated that Gc participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). The membrane-associated Gc chain interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds IL7 with a 3-
Last changed: 2015-03-06 00:07:54

Reaction: IL7RA associates with JAK1 (Homo sapiens)
IL7RA has the small juxta-membrane "Box1" motif, conserved throughout the type I cytokine receptor family (Murakami et al. 1991). This is believed to be the site of JAK1 binding (Tanner et al. 1995); deletion of Box1 eliminates JAK1 phosphorylation (Jiang et al. 2004). Studies with T-cell lines expressing mutant IL-4/IL-7 chimeric receptors revealed that loss of Box1 results in rapid cell death, while
Last changed: 2015-03-06 10:40:16

Reaction: IL7RA is phosphorylated on Y449 (Homo sapiens)
IL7 receptor signaling is presumed to resemble that of other Gc family cytokines, based on detailed studies of the IL2 receptor. Extending this model to IL7 suggests a similar series of events that bring JAK1 and JAK3 into proximity within a complex IL7:IL7RA:JAK1:Gc:JAK3. Cytoplasmic domains of the IL7 receptor chains orient so that their associated kinases (Janus and possibly phosphatidylinositol 3-k
Last changed: 2015-03-06 10:40:16

Reaction: Interleukin-7 binds IL7RA:JAK1 (Homo sapiens)
Interleukin-7 receptor alpha chain (IL7R) binds interleukin-7 (IL7), forming a stable 1:1 IL7:IL7R complex, with a dissociation constant (Kd) of approximately 200 pM (Goodwin et al. 1990, Park et al. 1990). The full-length IL7R is a 439-residue single-pass transmembrane glycoprotein consisting of three domains: a 219-residue extracellular domain (ECD), a 25-residue transmembrane domain and a 195-residu
Last changed: 2015-03-06 00:07:54

Reaction: p85 binds p(Y449)-IL7RA (Homo sapiens)
The p85 subunit of PI3K binds to phosphorylated Tyr-449 on IL7RA; Y449F substitution inhibits PI3K-dependent proliferation of IL7-stimulated murine B-lineage cells (Venkitaraman & Cowling 1994). Stimulation of human lymphocyte precursor cells with IL-7 induced tyrosine phosphorylation of the p85 subunit of PI3-kinase (PI3K) and activation of PI3K kinase activity (Dadi et al. 1994). It is thought
Last changed: 2015-03-06 10:40:16

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