Reactome: A Curated Pathway Database
Results 1 to 10 of 17
Pathways (6) Reactions (5) Proteins (1) Others (5)
Protein: UniProt:P18206 VCL (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Muscle contraction (Homo sapiens)
In this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated
Last changed: 2015-03-06 23:15:47

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2015-03-06 23:15:47

Pathway: Platelet activation, signaling and aggregation (Homo sapiens)
Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the platelet membrane (Ruggeri 2002). Intracellular signaling reactions then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. Once platelets have
Last changed: 2015-03-06 23:15:47

Pathway: Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platel
Last changed: 2015-03-06 23:15:47

Pathway: Smooth Muscle Contraction (Homo sapiens)
Layers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac muscle. Smooth muscle is triggered to contract by the autonomic nervous system, hormones, autocrine/paracrine agents, local chemical signals, and changes in load or length. Actin:myosin cross bridging i
Last changed: 2015-03-06 23:15:47

Pathway: Platelet degranulation (Homo sapiens)
Platelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules, dense granules and lysosomes. On activation platelets release a variety of proteins, largely from storage granules but also as the result of apparent cell lysis. These act in an autocrine or paracrine fas
Last changed: 2015-03-06 23:15:47

Reaction: Myosin Binds ATP (Homo sapiens)
With the expulsion of ADP from the nucleotide binding pocket, ATP, if available will immediately bind
Last changed: 2015-03-06 10:40:16

Reaction: Calcium Binds Caldesmon (Homo sapiens)
Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding
Last changed: 2015-03-06 10:40:16

Reaction: Release Of ADP From Myosin (Homo sapiens)
As soon as the actin and myosin filaments become competent for contraction, the swiveling head of myosin pulls itself along the actin filament. This movement changes the shape of the pocket to which ADP is bound, freeing the ADP molecule
Last changed: 2015-03-06 10:40:16

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