Reactome: A Curated Pathway Database
All 6 results
Pathways (4) Reactions (1) Proteins (1) Others (0)
Protein: UniProt:P18847 ATF3 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Metabolism of proteins (Homo sapiens)
Protein metabolism comprises the pathways of translation, post-translational modification and protein folding
Last changed: 2014-11-21 19:49:01

Pathway: Unfolded Protein Response (UPR) (Homo sapiens)
The Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER during times of unusually high secretion activity. Analysis of mutants with altered UPR, however, shows that the UPR is also required for normal development and function of secretory cells. One level at w
Last changed: 2014-11-21 19:49:01

Pathway: ATF4 activates genes (Homo sapiens)
ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3
Last changed: 2014-02-07 17:34:35

Pathway: PERK regulates gene expression (Homo sapiens)
PERK (EIF2AK3) is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintained in an inactive form by interaction of its luminal domain with BiP, an ER chaperone. BiP also binds unfolded proteins and so BiP dissociates from PERK when unfolded proteins accumulate in the ER. Dissociat
Last changed: 2014-11-21 14:40:22

Reaction: Expression of ATF3 (Homo sapiens)
The ATF3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein
Last changed: 2014-11-17 08:49:29