Reactome: A Curated Pathway Database
Results 1 to 10 of 12
Pathways (6) Reactions (2) Proteins (1) Others (3)
Protein: UniProt:P21912 SDHB (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2014-11-21 19:49:01

Pathway: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling p
Last changed: 2014-11-21 19:49:01

Pathway: The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to
Last changed: 2014-11-21 19:49:01

Pathway: Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Pyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the reversible oxidation of lactate or transamination of alanine, can be converted to acetyl CoA. Other sources of acetyl CoA include breakdown of free fatty acids and ketone bodies in the fasting state. Acetyl
Last changed: 2014-11-21 19:49:01

Pathway: Respiratory electron transport (Homo sapiens)
Mitochondria are often described as the "powerhouse" of a cell as it is here that energy is largely released from the oxidation of food. Reducing equivalents generated from beta-oxidation of fatty acids and from the Krebs cycle enter the electron transport chain (also called the respiratory chain ). During a series of redox reactions, electrons travel down the chain releasing
Last changed: 2014-11-21 19:49:01

Pathway: Citric acid cycle (TCA cycle) (Homo sapiens)
In the citric acid or tricarboxylic acid (TCA) cycle, the acetyl group of acetyl CoA (derived primarily from oxidative decarboxylation of pyruvate, beta-oxidation of long-chain fatty acids, and catabolism of ketone bodies and several amino acids) can be completely oxidized to CO2 in reactions that also yield one high-energy phosphate bond (as GTP or ATP) and four reducing equivalents (three NADH + H+,
Last changed: 2014-11-21 19:49:01

Reaction: Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
The succinate dehydrogenase complex, associated with the inner mitochondrial membrane, catalyzes the dehydrogenation of succinate to fumarate, reducing the FAD cofactor bound to the enzyme. This redox potential is then used in the electron transfer chain to drive a proton motive force to generate ATP
Last changed: 2014-11-21 14:40:22

Reaction: Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)
This event is deduced on the basis of bovine experimental data. Complex II (succinate dehydrogenase) transfers electrons from the TCA cycle to ubiquinone. The 6th step in the TCA cycle is where succinate is dehydrogenated to fumarate with subsequent reduction of FAD to FADH 2 . FADH 2 provides the electrons for the transport chain. Succinate dehydrogenase belongs to subclass 1 of
Last changed: 2014-11-21 14:40:22

Complex: Succinate dehydrogenase complex (oxidised) [mitochondrial inner membrane] (Homo sapiens)
Succinate dehydrogenase complex (oxidised)
Last changed: 2014-11-25 17:55:37

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