Reactome: A Curated Pathway Database
Results 1 to 10 of 11
Pathways (6) Reactions (3) Proteins (1) Others (1)
Protein: UniProt:P22309 UGT1A1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Phase II conjugation (Homo sapiens)
Phase II of biotransformation is concerned with conjugation , that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Al
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of porphyrins (Homo sapiens)
Porphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the name itself, porphyrin , is derived from the Greek word for purple . The aromatic character of porphyrins can be seen by NMR spectroscopy. Porphyrins readily combine with metals by coordinatin
Last changed: 2015-03-06 23:15:47

Pathway: Biological oxidations (Homo sapiens)
All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat so
Last changed: 2015-03-06 23:15:47

Pathway: Heme degradation (Homo sapiens)
Most of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not recycled so it must be degraded and excreted. The iron, however, is conserved. There are two steps to heme degradation; 1. cleavage of the heme ring by a microsomal heme oxygenase producing biliverdin 2.
Last changed: 2015-03-06 18:40:03

Pathway: Glucuronidation (Homo sapiens)
Glucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in phase II metabolism and accounts for approximately 35% of drug conjugation. UGTs are microsomal membrane-bound and catalyze the transfer of a glucuronate group of uridine diphosphoglucuronate (UDPGA, a co-s
Last changed: 2015-03-06 23:15:47

Reaction: UGT1A1 tetramer, UGT1A4 transfer GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)
The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). The monomeric forms of UGT1A1 (Bilirubin UDP-glucuronyltransferase 1) only conjugates the first step of bilirubin conjugation to form the monoglucuronide. A tetrameric form of UGT1A1 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuroni
Last changed: 2015-03-06 10:40:16

Reaction: UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)
Typical O-centred substrates were chosen as examples for these isozymes
Last changed: 2015-03-06 10:40:16

Reaction: UGT1A1,4 transfer GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)
Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 and 4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992). Mutations of the UGT1A1 gene
Last changed: 2015-03-06 10:40:16

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