Reactome: A Curated Pathway Database
All 8 results
Pathways (3) Reactions (1) Proteins (2) Others (2)
Protein: UniProt:P25942 CD40 (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Adaptive Immune System (Homo sapiens)
Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pat
Last changed: 2015-03-06 23:15:47

Pathway: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation.
Last changed: 2015-03-06 10:40:16

Protein: UniProt:P25942-1 CD40 (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Reaction: CD40L binds CD40 (Homo sapiens)
CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costim
Last changed: 2015-03-06 07:18:40

Complex: CD40:CD40L trimer [plasma membrane] (Homo sapiens)
CD40:CD40L trimer
Last changed: 2015-02-06 14:37:54

Complex: CD40 trimer [plasma membrane] (Homo sapiens)
CD40 trimer
Last changed: 2015-02-06 14:36:58