Reactome: A Curated Pathway Database
All 9 results
Pathways (5) Reactions (1) Proteins (1) Others (2)
Protein: UniProt:P26583 HMGB2 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Programmed Cell Death (Homo sapiens)
Cell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number of different forms of cell death, each with a corresponding number of complex subprocesses. The first form of regulated or programmed cell death to be characterized was apoptosis. Evidence has emerged for a
Last changed: 2015-03-06 23:15:47

Pathway: Apoptosis (Homo sapiens)
Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechani
Last changed: 2015-03-06 23:15:47

Pathway: Apoptotic execution phase (Homo sapiens)
In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003)
Last changed: 2015-03-06 23:15:47

Pathway: Activation of DNA fragmentation factor (Homo sapiens)
DNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed in Widlak and Garrard, 2005). In non-apoptotic cells, DFF is a nuclear heterodimer consisting of a 45 kD chaperone and inhibitor subunit (DFF45)/inhibitor of CAD (ICAD-L)] and a 40 kD nuclease subunit (
Last changed: 2015-03-06 18:40:03

Pathway: Apoptosis induced DNA fragmentation (Homo sapiens)
DNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in Widlak and Garrard, 2005). These endonucleases cleave chromatin producing 3'-hydroxyl groups and 5'-phosphate residues. 50-300 kb cleavage products are produced followed by inter
Last changed: 2015-03-06 18:40:03

Reaction: Association of HMGB1/HMGB2 with chromatin (Homo sapiens)
The major HMG-box-containing chromatin proteins HMGB1 and HMGB2 stimulate DNA cleavage by DFF40/CAD (Liu et al., 1998; Toh et al., 1998; Widlak et al., 2000). Changes in DNA conformation following HMG-box binding makes the substrate more accessible to cleavage by DFF40/CAD nuclease and thus may contribute to preferential linker DNA cleavage during apoptosis (Kalinowska-Herok and Widlak., 2008)
Last changed: 2015-03-06 18:40:03

Activation: 'HMGB1/HMGB2- bound chromatin [nucleoplasm]' positively regulates 'Cleavage of DNA by DFF40'
Last changed: 2014-07-07 23:05:45

Complex: HMGB1/HMGB2- bound chromatin [nucleoplasm] (Homo sapiens)
HMGB1/HMGB2- bound chromatin
Last changed: 2008-04-29 00:41:45