Reactome: A Curated Pathway Database
All 8 results
Pathways (6) Reactions (1) Proteins (1) Others (0)
Protein: UniProt:P29475 NOS1 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Disease (Homo sapiens)
Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally
Last changed: 2014-11-21 19:49:01

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2014-11-21 19:49:01

Pathway: Platelet homeostasis (Homo sapiens)
Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelia
Last changed: 2014-11-21 19:49:01

Pathway: Latent infection of Homo sapiens with Mycobacterium tuberculosis (Homo sapiens)
Infection by Mycobacterium tuberculosis ( Mtb ) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. A third of the world's population is estimated to harbour latent tu
Last changed: 2014-11-21 19:49:01

Pathway: Nitric oxide stimulates guanylate cyclase (Homo sapiens)
Nitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothelium, disaggregation of preformed platelet aggregates and inhibits activated platelet recruitment to the aggregate. NO is synthesized from L-arginine by a family of isoformic enzymes known as nitric oxide
Last changed: 2014-11-21 14:40:22

Pathway: Phagosomal maturation (early endosomal stage) (Homo sapiens)
Alveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized Mtb , this development is arrested at an early stage and only includes acidification, nitric oxide and superoxide production, as well as the use of a few other proteins that can be gained from other endosomes which still can interact with the phagosome (Flannagan et al. 2009)
Last changed: 2014-11-21 19:49:01

Reaction: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
Nitric oxide synthase (NOS) produces NO from L-arginine. There are three isoforms of NOS, endothelial, neuronal and inducible (eNOS, nNOS, and iNOS). eNOS and nNOS are constitutively expressed while iNOS is induced by immunostimulatory signals. The constitutive isoforms are regulated in vivo by the binding of calcium and calmodulin. NO produced by NOS acts as a signalling molecule by diffusing across c
Last changed: 2014-11-21 14:40:22