Reactome: A Curated Pathway Database
Results 1 to 10 of 27
Pathways (12) Reactions (8) Proteins (1) Others (6)
Protein: UniProt:P38398 BRCA1 (Homo sapiens)
Last changed: 2014-11-25 21:16:27

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: DNA Repair (Homo sapiens)
DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair adducts that arise. DNA damage can arise spontaneously in the cellular milieu through chemical alteration of base nucleotides or as a consequence of errors during DNA replication. For example, it is well k
Last changed: 2014-11-21 19:49:01

Pathway: Fanconi Anemia pathway (Homo sapiens)
Fanconi anemia (FA) is a genetic disease of genome instability characterized by congenital skeletal defects, aplastic anemia, susceptibility to leukemias, and cellular sensitivity to DNA damaging agents. Patients with FA have been categorized into at least 13 complementation groups (FA-A, -B, -C, -D1, -D2, -E, -F, -G, -I, -J, -L, -M, and -N). These complementation groups correspond to the genes FANCA,
Last changed: 2014-11-21 19:49:01

Pathway: Meiotic synapsis (Homo sapiens)
Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination trans
Last changed: 2014-11-21 06:36:34

Pathway: Meiosis (Homo sapiens)
During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregat
Last changed: 2014-11-21 19:49:01

Pathway: Double-Strand Break Repair (Homo sapiens)
Numerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-strand breaks (DSBs), one of the most dangerous type of DNA damage along with interstrand crosslinks, are caused by ionizing radiation or certain chemicals such as bleomycin, and occur normally during the pr
Last changed: 2014-11-21 19:49:01

Pathway: Meiotic recombination (Homo sapiens)
Meiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). There are two forms of recombination: non-crossover (NCO) and crossover (CO). In mammals, the former is required for correct pairing and synapsis of homologous chromosomes, while CO intermediates called chiasma
Last changed: 2014-11-21 19:49:01

Pathway: Homologous recombination repair of replication-independent double-strand breaks (Homo sapiens)
Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand
Last changed: 2014-11-21 19:49:01

Pathway: Homologous Recombination Repair (Homo sapiens)
The HRR pathway is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs). HRR acts on DSBs occurring within replicated DNA (replication-independent DSBs) or on DSBs that are generated at broken replication forks (replication-dependent DSBs). Repair by homologous recombination involves processing of the ends of the DNA double
Last changed: 2014-11-21 19:49:01

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