Reactome: A Curated Pathway Database
All 7 results
Pathways (4) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:P40394 ADH7 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Phase 1 - Functionalization of compounds (Homo sapiens)
Phase 1 of metabolism is concerned with functionalization , that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemical
Last changed: 2015-03-06 23:15:47

Pathway: Biological oxidations (Homo sapiens)
All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat so
Last changed: 2015-03-06 23:15:47

Pathway: Ethanol oxidation (Homo sapiens)
Ethanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep process first described by Racker (1949). First, in the cytosol, ethanol is oxidized to acetaldehyde, with the formation of NADH. Second, in the mitochondrion, acetaldehyde is oxidized to acetate with the f
Last changed: 2015-03-06 23:15:47

Reaction: ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)
Cytosolic alcohol dehydrogenase catalyzes the reaction of ethanol and NAD+ to form acetaldehyde and NADH + H+. The active form of the enzyme is a dimer with one zinc ion bound to each protein subunit. In the body, alcohol dehydrogenase is present in the liver, kidney, lung and gastric mucosa. Six genes encode proteins active in ethanol oxidation: ADH1A, ADH1B, ADH1C, ADH4, ADH6, and ADH7 (Lange et al
Last changed: 2015-03-12 13:50:51

Complex: ADH7:2Zn2+ dimer [cytosol] (Homo sapiens)
ADH7:2Zn2+ dimer; alcohol dehydrogenase 7 (class IV), mu or sigma dimer
Last changed: 2014-05-01 15:48:31