Reactome: A Curated Pathway Database
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Pathways (7) Reactions (9) Proteins (1) Others (10)
Protein: UniProt:P42768 WAS (Homo sapiens)
Last changed: 2014-11-25 20:54:06

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2014-11-21 19:49:01

Pathway: Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs
Last changed: 2014-11-21 19:49:01

Pathway: Innate Immune System (Homo sapiens)
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Last changed: 2014-11-21 19:49:01

Pathway: Adaptive Immune System (Homo sapiens)
Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pat
Last changed: 2014-11-21 19:49:01

Pathway: TCR signaling (Homo sapiens)
The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-
Last changed: 2014-11-21 19:49:01

Pathway: Generation of second messenger molecules (Homo sapiens)
In addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have been recognized to play pivotal role in TCR signaling by releasing second messengers. When phosphorylated, LAT and SLP-76 act as adaptor proteins which serve as nucleation points for the construction of a hig
Last changed: 2014-11-21 19:49:01

Pathway: Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extens
Last changed: 2014-11-21 14:40:22

Reaction: NCK recruits WASP (Homo sapiens)
The second SH3 domain of NCK interacts with the carboxy-terminal SH3 domain of WASP. WASP family proteins bind the Arp2/3 complex, stimulating its ability to nucleate actin filaments and induce filament branching
Last changed: 2014-11-21 06:36:34

Polymerisation: Branching and elongation of mother and daughter filaments (Homo sapiens)
ATP bound G-actin monomers are added to the fast growing barbed ends of both the mother and the daughter filaments and the polymerization of these filaments drives membrane protrusion. Pseudopodia extend around the antibody bound particle to form the phagocytic cup. This elongation continues until the filament reaches a steady state equilibrium with free G-actin monomers
Last changed: 2014-11-21 14:40:22

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