Reactome: A Curated Pathway Database
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Pathways (5) Reactions (14) Proteins (2) Others (15)
Protein: UniProt:P48551 IFNAR2 (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Cytokine Signaling in Immune system (Homo sapiens)
Cytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concentrations. Cytokines bind to specific membrane receptors, which then signal the cell via second messengers, to regulate cellular activity
Last changed: 2015-03-06 23:15:47

Pathway: Interferon Signaling (Homo sapiens)
Interferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others, such as omega, epsilon, and kappa), Type II (IFN-gamma) and Type III (IFN-lamda). In this module we are mainly focusing on type I IFNs alpha and beta and type II IFN-gamma. Both type I and type II IFNs ex
Last changed: 2015-03-06 23:15:47

Pathway: Interferon alpha/beta signaling (Homo sapiens)
Type I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, whereas there is only one IFNB gene. The large family of IFNA/B proteins all bind to a single receptor which is composed of two distinct chains: IFNAR1 and IFNAR2. The IFNA/B stimulation of the IFNA receptor co
Last changed: 2015-03-06 10:40:16

Protein: UniProt:P48551-2 IFNAR2 (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Regulation of IFNA signaling (Homo sapiens)
There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as w
Last changed: 2015-03-06 10:40:16

Reaction: Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
SHP1 directly associates with and dephosphorylates JAK1/2
Last changed: 2015-03-06 10:40:16

Reaction: Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701
Last changed: 2015-03-06 10:40:16

Reaction: UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
UBP43, a type I IFN-inducible cysteine protease acts as a negative regulator of type I IFN signaling. UBP43 binds directly to IFNAR2 and blocks JAK-receptor interaction leading to inhibition of downstream phosphorylation and other signaling events
Last changed: 2015-03-06 05:19:08

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