Reactome: A Curated Pathway Database
All 6 results
Pathways (2) Reactions (1) Proteins (1) Others (2)
Protein: UniProt:P49768 PSEN1 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Extracellular matrix organization (Homo sapiens)
The extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded in a viscoelastic gel of anionic proteoglycan polymers. It performs many functions in addition to its structural role; as a major component of the cellular microenvironment it influences cell behaviours su
Last changed: 2014-11-21 14:40:22

Pathway: Degradation of the extracellular matrix (Homo sapiens)
Matrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the metzincin family. They contain a characteristic zinc-binding motif HEXXHXXGXXH (Stocker & Bode 1995) and a conserved Methionine which forms a Met-turn. Humans have 24 MMP genes giving rise to 23 MMP protei
Last changed: 2014-11-21 14:40:22

Reaction: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)
E-cadherin (CDH1) localizes to the lateral membrane of differentiated epithelia, providing the structural foundation for adherens junctions, multiprotein complexes that link cell-cell contacts to the actin cytoskeleton and various signaling molecules (Perez-Moreno et al. 2003, Baum & Georgiou 2011). The extracellular domain has five cadherin-type repeat ectodomain (EC) modules; the most membrane-distal
Last changed: 2014-11-21 06:36:34

Complex: PS1 [plasma membrane] (Homo sapiens)
PS1; Presenillin-1
Last changed: 2012-10-24 16:11:40

Complex: PS1:NCSTN [plasma membrane] (Homo sapiens)
PS1:NCSTN; Gamma-secretase (minimal); Presenilin-1:nicastrin
Last changed: 2012-10-24 16:11:40