Reactome: A Curated Pathway Database
Results 1 to 10 of 13
Pathways (4) Reactions (2) Proteins (1) Others (6)
Protein: UniProt:P52945 PDX1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2015-03-06 23:15:47

Pathway: Regulation of beta-cell development (Homo sapiens)
The normal development of the pancreas during gestation has been intensively investigated over the past decade especially in the mouse (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). Studies of genetic defects associated with maturity onset diabetes of the young (MODY) has provided direct insight into these processes as they take place in humans (Fajans et al. 2001). During embryogenesis, com
Last changed: 2015-03-06 23:15:47

Pathway: Regulation of gene expression in early pancreatic precursor cells (Homo sapiens)
The properties of transcriptional networks early in the differentiation of human pancreatic cells are inferred from the properties of well-studied networks in mouse models. In mice, the first visible sign of pancreatic development is the appearance of pancreatic buds at about embryonic day 9. The cells in these buds are already committed to differentiate into specialized cells of the exocrine and endoc
Last changed: 2015-03-06 18:40:03

Pathway: Regulation of gene expression in beta cells (Homo sapiens)
Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expressio
Last changed: 2015-03-06 23:15:47

Reaction: HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)
The PDX1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription requires the activities of the HNF6 transcription factor and FGF10. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse
Last changed: 2015-03-06 10:40:16

Reaction: FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)
The PDX1 (IPF1) gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription is positively regulated by the activities of the FOXA2, MAFA, and PAX6 transcription factors. It is negatively regulated by FOXO1A, so events that deplete the nucleoplasmic pool of FOXO1A increase expression of PDX1. These events and interactions have not been studied d
Last changed: 2015-03-06 10:40:16

Activation: 'PDX1 [nucleoplasm]' positively regulates 'PDX1-dependent synthesis of NR5A2 protein'
Last changed: 2008-01-29 21:29:24

Activation: 'PDX1 [nucleoplasm]' positively regulates 'PDX1-dependent synthesis of NKX6-1 protein'
Last changed: 2008-01-29 21:29:24

Activation: 'PDX1 [nucleoplasm]' positively regulates 'NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein'
Last changed: 2010-04-29 21:40:02

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