Reactome: A Curated Pathway Database
All 7 results
Pathways (3) Reactions (2) Proteins (1) Others (1)
Protein: UniProt:P54132 BLM (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2014-11-21 19:49:01

Pathway: Meiosis (Homo sapiens)
During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregat
Last changed: 2014-11-21 19:49:01

Pathway: Meiotic recombination (Homo sapiens)
Meiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). There are two forms of recombination: non-crossover (NCO) and crossover (CO). In mammals, the former is required for correct pairing and synapsis of homologous chromosomes, while CO intermediates called chiasma
Last changed: 2014-11-21 19:49:01

Reaction: Resolution of meiotic holliday junction (Homo sapiens)
Meiotic Holliday junctions are cleaved to yield either crossovers or non?crossovers (gene conversions). The resolvase or resolvases responsible for cleavage are unknown but a resolvase complex may include SLX4 and/or GEN1. Two classes of crossovers have been defined: class I crossovers are dependent on the MutL homologs, MLH1 and MLH3, while class II crossovers are dependent on the MUS81-EME1 endon
Last changed: 2014-11-21 06:36:34

Reaction: Formation of meiotic holliday junction (Homo sapiens)
The 3' end of the invading strand is extended by an unknown DNA polymerase and the extended strand is then ligated back to the original homolog, generating a double Holliday junction. MSH4 and MSH5 form heterodimers which bind Holliday junctions and, in the presence of ATP, slide along the parental duplexes (Bocker et al. 1999, Snowden et al. 2004, Snowden et al. 2008). MSH4 is present at hundreds of m
Last changed: 2014-11-21 06:36:34

Complex: Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction
Last changed: 2010-10-04 08:59:14