Reactome: A Curated Pathway Database
Results 1 to 10 of 13
Pathways (8) Reactions (3) Proteins (1) Others (1)
Protein: UniProt:P54132 BLM (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Metabolism of proteins (Homo sapiens)
Protein metabolism comprises the pathways of translation, post-translational modification and protein folding
Last changed: 2015-03-06 23:15:47

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Meiosis (Homo sapiens)
During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregat
Last changed: 2015-03-06 23:15:47

Pathway: Post-translational protein modification (Homo sapiens)
After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid o
Last changed: 2015-03-06 23:15:47

Pathway: SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro and Chiocca 2013, Yang and Chiang 2013). Proteomic analyses indicate that SUMO is conjugated to hundreds of proteins and most targets of SUMOylation are nuclear (Vertegal et al. 2006, Bruderer et al. 2011,
Last changed: 2015-03-06 23:15:47

Pathway: Meiotic recombination (Homo sapiens)
Meiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). There are two forms of recombination: non-crossover (NCO) and crossover (CO). In mammals, the former is required for correct pairing and synapsis of homologous chromosomes, while CO intermediates called chiasma
Last changed: 2015-03-06 23:15:47

Pathway: SUMOylation of DNA damage response and repair proteins (Homo sapiens)
Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thym
Last changed: 2015-03-06 23:15:47

Pathway: SUMOylation (Homo sapiens)
Small Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Hay 2013, Hannoun et al. 2010, Gareau and Lima 2010, Wilkinson and Henley 2010, Wang and Dasso 2009). Proteomic methods have yielded estimates of hundreds of target proteins. Targets are mostly located in the
Last changed: 2015-03-06 23:15:47

Reaction: Resolution of meiotic holliday junction (Homo sapiens)
Meiotic Holliday junctions are cleaved to yield either crossovers or non?crossovers (gene conversions). The resolvase or resolvases responsible for cleavage are unknown but a resolvase complex may include SLX4 and/or GEN1. Two classes of crossovers have been defined: class I crossovers are dependent on the MutL homologs, MLH1 and MLH3, while class II crossovers are dependent on the MUS81-EME1 endon
Last changed: 2015-03-06 10:40:16

1 2 Next >
Show all results