Reactome: A Curated Pathway Database
All 8 results
Pathways (5) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:P55809 OXCT1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Fatty acid, triacylglycerol, and ketone body metabolism (Homo sapiens)
The reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central role in human energy metabolism
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of lipids and lipoproteins (Homo sapiens)
Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins. They function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constitue
Last changed: 2015-03-06 23:15:47

Pathway: Ketone body metabolism (Homo sapiens)
Acetoacetate, beta-hydroxybutyrate, and acetone collectively are called ketone bodies. The first two are synthesized from acetyl-CoA, in the mitochondria of liver cells; acetone is formed by spontaneous decarboxylation of acetoacetate. Ketone body synthesis in liver is effectively irreversible because the enzyme that catalyzes the conversion of acetoacetate to acetoacetyl-CoA is not present in liver ce
Last changed: 2015-03-06 23:15:47

Pathway: Utilization of Ketone Bodies (Homo sapiens)
The levels of acetone in ketone bodies are much lower than those of acetoacetic acid and beta-hydroxybutyric acid. Acetone cannot be converted back to acetyl-CoA, and is excreted in urine, or breathed out through the lungs. Extrahepatic tissues utilize ketone bodies by converting the beta-hydroxybutyrate successively to acetoacetate, acetoacetatyl-CoA, finally to acetyl-CoA (Sass 2011)
Last changed: 2015-03-06 23:15:47

Reaction: acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate (Homo sapiens)
3-Oxoacid CoA-transferase dimer (OXCT1) in the mitochondrial matrix catalyzes the reversible reaction of acetoacetate and succinyl-CoA to form acetoacetyl-CoA and succinate (Kassovska-Bratinova et al. 1996)
Last changed: 2015-03-12 13:50:51

Complex: OXCT1 dimer [mitochondrial matrix] (Homo sapiens)
OXCT1 dimer; 3-oxoacid CoA-transferase homodimer
Last changed: 2010-03-19 22:40:43