Reactome: A Curated Pathway Database
All 6 results
Pathways (4) Reactions (1) Proteins (1) Others (0)
Protein: UniProt:Q08357 SLC20A2 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+ - and/or Cl- -dependent transport of basic anions [e.g. HCO3-, (CO3)2-] in various tissues and cell types (in additi
Last changed: 2015-03-06 23:15:47

Pathway: SLC-mediated transmembrane transport (Homo sapiens)
Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates (ions or water) down their electrochemical gradient, at an extre
Last changed: 2015-03-06 23:15:47

Pathway: Sodium-coupled phosphate cotransporters (Homo sapiens)
Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (fr
Last changed: 2015-03-06 23:15:47

Reaction: SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)
There are two transporters of this type; The genes SLC20A1 and SLC20A2 encode for phosphate transporters 1 and 2 (PiT1 and PiT2 respectively). They both have a broad tissue distribution and may play a general housekeeping role in phosphate transport such as absorbing phosphate from interstitial fluid and in extracellular matrix and cartilage calcification as well as in vascular calcification. These pro
Last changed: 2015-03-06 23:15:47