Reactome: A Curated Pathway Database
All 8 results
Pathways (4) Reactions (2) Proteins (1) Others (1)
Protein: UniProt:Q12882 DPYD (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2014-11-21 19:49:01

Pathway: Metabolism of nucleotides (Homo sapiens)
Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotid
Last changed: 2014-11-21 19:49:01

Pathway: Pyrimidine catabolism (Homo sapiens)
In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids
Last changed: 2014-11-21 19:49:01

Pathway: Pyrimidine metabolism (Homo sapiens)
The events of human pyrimidine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of the pyrimidine ring and its conversion to uridine 5'-monophosphate (UMP), the biosynthesis of other pyrimidine ribo- and deoxyribonucleotides, pyrimidine salvage reactions, and pyrimidine catabolism (Loffler et al. 2005). De novo synthesis of the pyrimidine ring and
Last changed: 2014-11-21 19:49:01

Reaction: uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994)
Last changed: 2014-11-25 21:08:03

Reaction: thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of thymine and NADPH + H+ to form 5,6-dihydrothymine and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994)
Last changed: 2014-11-21 19:49:01

Complex: DPYD dimer [cytosol] (Homo sapiens)
DPYD dimer; DHUdehydrogenase-Fe-2FAD-2FMN complex
Last changed: 2010-05-03 18:25:40